Gene–environment interactions in human health
Gene–environment interactions (G× E), the interplay of genetic variation with environmental
factors, have a pivotal impact on human complex traits and diseases. Statistically, G× E can …
factors, have a pivotal impact on human complex traits and diseases. Statistically, G× E can …
Statistical methods for gene–environment interaction analysis
Most human complex phenotypes result from multiple genetic and environmental factors and
their interactions. Understanding the mechanisms by which genetic and environmental …
their interactions. Understanding the mechanisms by which genetic and environmental …
Pathway Polygenic Risk Scores (pPRS) for the Analysis of Gene-environment Interaction
WJ Gauderman, Y Fu, B Quem, E Kawaguchi, Y Wang… - bioRxiv, 2024 - biorxiv.org
A polygenic risk score (PRS) is used to quantify the combined disease risk of many genetic
variants. For complex human traits there is interest in determining whether the PRS modifies …
variants. For complex human traits there is interest in determining whether the PRS modifies …