[HTML][HTML] Essentials of oral cancer

C Rivera - International journal of clinical and experimental …, 2015 - ncbi.nlm.nih.gov
Oral cancer is one of the 10 most common cancers in the world, with a delayed clinical
detection, poor prognosis, without specific biomarkers for the disease and expensive …

NADPH oxidases and cancer

K Roy, Y Wu, JL Meitzler, A Juhasz, H Liu… - Clinical …, 2015 - portlandpress.com
The mechanism by which reactive oxygen species (ROS) are produced by tumour cells
remained incompletely understood until the discovery over the last 15 years of the family of …

Multi-omic measurements of heterogeneity in HeLa cells across laboratories

Y Liu, Y Mi, T Mueller, S Kreibich, EG Williams… - Nature …, 2019 - nature.com
Reproducibility in research can be compromised by both biological and technical variation,
but most of the focus is on removing the latter. Here we investigate the effects of biological …

[HTML][HTML] Integration of machine learning and genome-scale metabolic modeling identifies multi-omics biomarkers for radiation resistance

JE Lewis, ML Kemp - Nature Communications, 2021 - nature.com
Resistance to ionizing radiation, a first-line therapy for many cancers, is a major clinical
challenge. Personalized prediction of tumor radiosensitivity is not currently implemented …

Efficacy, long-term toxicity, and mechanistic studies of gold nanorods photothermal therapy of cancer in xenograft mice

MRK Ali, MA Rahman, Y Wu, T Han… - Proceedings of the …, 2017 - National Acad Sciences
Gold nanorods (AuNRs)-assisted plasmonic photothermal therapy (AuNRs-PPTT) is a
promising strategy for combating cancer in which AuNRs absorb near-infrared light and …

Identification of the cell-intrinsic and-extrinsic pathways downstream of EGFR and IFNγ that induce PD-L1 expression in head and neck cancer

F Concha-Benavente, RM Srivastava, S Trivedi, Y Lei… - Cancer research, 2016 - AACR
Many cancer types, including head and neck cancers (HNC), express programmed death
ligand 1 (PD-L1). Interaction between PD-L1 and its receptor, programmed death 1 (PD-1) …

Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers

CR Pickering, J Zhang, SY Yoo, L Bengtsson… - Cancer discovery, 2013 - AACR
The survival of patients with oral squamous cell carcinoma (OSCC) has not changed
significantly in several decades, leading clinicians and investigators to search for promising …

Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis

L Jin, J Chun, C Pan, GN Alesi, D Li, KR Magliocca… - Oncogene, 2017 - nature.com
Metastases remain the major cause of death from cancer. Recent molecular advances have
highlighted the importance of metabolic alterations in cancer cells, including the Warburg …

Recurrent Fusions in MYB and MYBL1 Define a Common, Transcription Factor–Driven Oncogenic Pathway in Salivary Gland Adenoid Cystic Carcinoma

KJ Brayer, CA Frerich, H Kang, SA Ness - Cancer discovery, 2016 - AACR
Adenoid cystic carcinoma (ACC), the second most common malignancy of salivary glands, is
a rare tumor with a bleak prognosis for which therapeutic targets are unavailable. We used …

CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover

SJ Stehbens, M Paszek, H Pemble, A Ettinger… - Nature cell …, 2014 - nature.com
Turnover of integrin-based focal adhesions (FAs) with the extracellular matrix (ECM) is
essential for coordinated cell movement. In collectively migrating human keratinocytes, FAs …