The cardiometabolic syndrome (CMS) and obesity are typically characterized by a state of
metabolic insulin resistance. As global and US rates of obesity increase there is an …

This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular
filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80 …

The epithelial sodium channel (ENaC) is composed of three homologous subunits and
allows the flow of Na+ ions across high resistance epithelia, maintaining body salt and water …

During the development of the pulmonary vasculature in the fetus, many structural and
functional changes occur to prepare the lung for the transition to air breathing. The …

Angiogenesis is the growth of blood vessels from the existing vasculature. The field of
angiogenesis has grown enormously in the past 30 years, with only 40 papers published in …

Advances in retinal imaging are enabling researchers and clinicians to make precise
noninvasive measurements of the retinal vasculature in vivo. This includes measurements of …

Transient receptor potential (TRP) proteins constitute a large non-voltage-gated cation
channel superfamily, activated polymodally by various physicochemical stimuli, and are …

Blood vessels are subjected to mechanical loads of pressure and flow, inducing smooth
muscle circumferential and endothelial shear stresses. The perception and response of …