[HTML][HTML] Targeted inhibition of STAT3 as a potential treatment strategy for atherosclerosis

Q Chen, J Lv, W Yang, B Xu, Z Wang, Z Yu, J Wu… - Theranostics, 2019 - ncbi.nlm.nih.gov
Atherosclerosis is the main pathological basis of ischemic cardiovascular and
cerebrovascular diseases and has attracted more attention in recent years. Multiple studies …

STAT3 and apoptosis challenges in cancer

N Fathi, G Rashidi, A Khodadadi, S Shahi… - International journal of …, 2018 - Elsevier
Several studies have processed conceivable evidence for the vital role of Signal Transducer
and Activator of Transcription 3 (STAT3) in cancer transformation and carcinogenesis …

Chlorinated organophosphate flame retardants impair the lung function via the IL-6/JAK/STAT signaling pathway

H Zhu, H Zhang, K Lu, S Yang, X Tang… - Environmental …, 2022 - ACS Publications
Toxicological studies have revealed the adverse impacts of organophosphate flame
retardants (OPFRs) on the respiratory system, while there is a lack of epidemiological …

Extracellular traps from activated vascular smooth muscle cells drive the progression of atherosclerosis

M Zhai, S Gong, P Luan, Y Shi, W Kou, Y Zeng… - Nature …, 2022 - nature.com
Extracellular DNA traps (ETs) represent an immune response by which cells release
essential materials like chromatin and granular proteins. Previous studies have …

Hypoxia and STAT3 signalling interactions regulate pro-inflammatory pathways in rheumatoid arthritis

W Gao, J McCormick, M Connolly, E Balogh… - Annals of the …, 2015 - ard.bmj.com
Objective To examine the effect of hypoxia on Signal Transducer and Activator of
Transcription 3 (STAT3)-induced pro-inflammatory pathways in rheumatoid arthritis (RA) …

Inhibition of miR-92a improves re-endothelialization and prevents neointima formation following vascular injury

JM Daniel, D Penzkofer, R Teske… - Cardiovascular …, 2014 - academic.oup.com
Abstract Aims MicroRNA (miR)-92a is an important regulator of endothelial proliferation and
angiogenesis after ischaemia, but the effects of miR-92a on re-endothelialization and …

Therapeutic targeting of the proinflammatory IL‐6‐JAK/STAT signalling pathways responsible for vascular restenosis in type 2 diabetes mellitus

FT Moshapa, K Riches-Suman… - Cardiology research and …, 2019 - Wiley Online Library
Type 2 diabetes mellitus (T2DM) is increasing worldwide, and it is associated with increased
risk of coronary artery disease (CAD). For T2DM patients, the main surgical intervention for …

Emerging translational approaches to target STAT3 signalling and its impact on vascular disease

J Dutzmann, JM Daniel, J Bauersachs… - Cardiovascular …, 2015 - academic.oup.com
Acute and chronic inflammation responses characterize the vascular remodelling processes
in atherosclerosis, restenosis, pulmonary arterial hypertension, and angiogenesis. The …

Repurposing nitazoxanide as a novel anti‐atherosclerotic drug based on mitochondrial uncoupling mechanisms

MH Ma, FF Li, WF Li, H Zhao, M Jiang… - British Journal of …, 2023 - Wiley Online Library
Background and Purpose The anthelmintic drug nitazoxanide has a mitochondrial
uncoupling effect. Mitochondrial uncouplers have been proven to inhibit smooth muscle cell …

STAT3 protein regulates vascular smooth muscle cell phenotypic switch by interaction with myocardin

XH Liao, N Wang, DW Zhao, DL Zheng, L Zheng… - Journal of Biological …, 2015 - ASBMB
The JAK-STAT3 signaling pathway is one of the critical pathways regulating cell
proliferation, differentiation, and apoptosis. Myocardin is regarded as a key mediator for the …