Hexokinases are a family of ubiquitous exose-phosphorylating enzymes that prime glucose
for intracellular utilization. Hexokinase 2 (HK2) is the most active isozyme of the family …

Tumor formation and growth depend on various biological metabolism processes that are
distinctly different with normal tissues. Abnormal energy metabolism is one of the typical …

The emergence of OpenAI's ChatGPT has put intense spotlight on Generative AI (Gen-AI)
systems and their possible impacts on Academic integrity. This paper provides an overview …

Glycolysis is a tightly regulated process in which several enzymes, such as Hexokinases
(HKs), play crucial roles. Cancer cells are characterized by specific expression levels of …

Aerobic glycolysis, ie., the Warburg effect, may contribute to the aggressive phenotype of
hepatocellular carcinoma. However, increasing evidence highlights the limitations of the …

Acute myeloid leukemias (AML) are a group of aggressive hematologic malignancies
resulting from acquired genetic mutations in hematopoietic stem cells that affect patients of …

Women with metabolic disorders, including obesity and diabetes, have an increased risk of
developing endometrial cancer. However, the metabolism of endometrial tumors themselves …

At the beginning of the twenty-first century, 3-bromopyruvate (3BP), a simple alkylating
chemical compound was presented to the scientific community as a potent anticancer agent …

During the last few years, the understanding of the dysregulated hydrogen ion dynamics and
reversed proton gradient of cancer cells has resulted in a new and integral pH-centric …

An increased metabolic flux towards Warburg phenotype promotes survival, proliferation
and causes therapeutic resistance, in leukemic cells. Hexokinase-II (HK-II) is expressed …