Wnt signaling is one of a handful of powerful signaling pathways that play crucial roles in the
animal life by controlling the genetic programs of embryonic development and adult …

The last few years have seen major advances in common non-syndromic obesity research,
much of it the result of genetic studies. This Review outlines the competing hypotheses …

Host cellular receptors play key roles in the determination of virus tropism and pathogenesis.
However, little is known about SARS-CoV-2 host receptors with the exception of ACE2 …

The mammalian hair follicle is a complex 'mini-organ'thought to form only during
development; loss of an adult follicle is considered permanent. However, the possibility that …

Wnt/β-catenin signaling plays key roles in tooth development, but how this pathway
intersects with the complex interplay of signaling factors regulating dental morphogenesis …

Leucine-rich repeat-containing G protein-coupled receptor 5 (Lgr5) and its homologs (eg,
Lgr6) mark adult stem cells in multiple tissues. Recently, we and others have shown that …

The sense of taste, or gustation, is mediated by taste buds, which are housed in specialized
taste papillae found in a stereotyped pattern on the surface of the tongue. Each bud …

Wnt/β-catenin and NF-κB signaling mechanisms provide central controls in development
and disease, but how these pathways intersect is unclear. Using hair follicle induction as a …

The creation of molecular tools able to unravel in vivo spatiotemporal activation of specific
cell signaling events during cell migration, differentiation and morphogenesis is of great …

The Wnt/β-catenin signaling pathway is one of several key conserved intercellular signaling
pathways in animals, and plays fundamental roles in the proliferation, regeneration …