In contrast to the approach commonly taken by chemists, nature controls chemical reactivity
by modulating the effective molarity of highly dilute reactants through macromolecule …

Interest in cleavable linkers is growing due to the rapid development and expansion of
chemical biology. The chemical constrains imposed by the biological conditions cause …

Recent developments show encouraging results for the use of DNA as a construction
material for nanometer‐sized objects. Today, however, DNA‐based molecular …

DNA (deoxyribonucleic acid) is the genetic material common to all of Earth's organisms. Our
biological understanding of DNA is extensive and well‐exploited. In recent years, chemists …

Sensing nucleic acid sequences is critical in modern-day biology and medicine, and is likely
to continue to increase in importance over the next 10r20 years. The current uses for …

Catalytic signal enhancement using an organometallic reaction is demonstrated. The
reactivity of a Heck cross-coupling reaction that creates a fluorophore is modulated by the …

The programmability of oligonucleotide recognition offers an attractive platform to direct the
assembly of reactive partners that can engage in chemical reactions. Recently, significant …

We report DNA-scaffolded synergistic catalysis, a concept that combines the diverse
reaction scope of synergistic catalysis with the ability of DNA to precisely preorganize abiotic …

Herein we describe a novel DNA-catalyzed transfer of a reporter group from a donating to an
accepting oligo-peptide nucleic acid (PNA), generating high catalytic turnover numbers in a …

Templated reactions have frequently been applied in nucleic acid chemistry as well as in
synthetic chemistry to facilitate conversions that proceed less efficiently when performed in …