Emerging radiotherapy treatments including targeted particle therapy, hadron therapy or
radiosensitisation of cells by high-Z nanoparticles demand the theoretical determination of …

G eant 4 is a software toolkit for the simulation of the passage of particles through matter. It is
used by a large number of experiments and projects in a variety of application domains …

The Geant4-DNA project proposes to develop an open-source simulation software based
and fully included in the general-purpose Geant4 Monte-Carlo simulation toolkit. The main …

The increased specificity of targeting agents has resulted in an interest in the use of
radionuclides that emit particulate radiation: alpha particles, beta particles and Auger …

Microbeam facilities provide a unique opportunity to investigate the effects of ionising
radiation on living biological cells with a precise control of the delivered dose. This paper …

Purpose: This study aimed to develop a computational environment for the accurate
simulation of human cancer cell irradiation using Geant4-DNA. New cell geometrical models …

Targeted alpha therapy (TAT) has the advantage of delivering therapeutic doses to
individual cancer cells while reducing the dose to normal tissues. TAT applications relate to …

As a consequence of the high potency and short range of alpha-particles,
radiopharmaceutical therapy with alpha-particle emitting radionuclides is a promising …

Mathematical and stochastic computer (in silico) models of tumour growth and treatment
response of the past and current eras are presented, outlining the aims of the models, model …

To investigate the impact of conformational properties of genetic material of living cells on
radiation-induced DNA damage, single strand breaks (SSB), double strand breaks (DSB) …