Airway remodeling heterogeneity in asthma and its relationship to disease outcomes

A Hsieh, N Assadinia, TL Hackett - Frontiers in physiology, 2023 - frontiersin.org
Asthma affects an estimated 262 million people worldwide and caused over 461,000 deaths
in 2019. The disease is characterized by chronic airway inflammation, reversible …

The role of the endothelium in asthma and chronic obstructive pulmonary disease (COPD)

CE Green, AM Turner - Respiratory research, 2017 - Springer
COPD and asthma are important chronic inflammatory disorders with a high associated
morbidity. Much research has concentrated on the role of inflammatory cells, such as the …

Pathophysiology of asthma

PJ Barnes, JM Drazen - Asthma and COPD, 2002 - Elsevier
Publisher Summary Asthma and chronic obstructive pulmonary disease (COPD) are highly
complex airway-obstruction disease conditions. Chronic inflammation of airways is …

The current and future role of biomarkers in type 2 cytokine‐mediated asthma management

ID Pavord, S Afzalnia, A Menzies‐Gow… - Clinical & …, 2017 - Wiley Online Library
Assessment and management of asthma is complicated by the heterogeneous
pathophysiological mechanisms that underlie its clinical presentation, which are not …

Rapid effects of inhaled corticosteroids in acute asthma: an evidence-based evaluation

GJ Rodrigo - Chest, 2006 - Elsevier
Background Current reviews on the use of inhaled corticosteroids (ICS) for acute asthma
underestimated their early (minutes) clinical impact and produced conclusions of …

Airway remodeling in asthma: therapeutic implications of mechanisms

RJ Homer, JA Elias - Physiology, 2005 - journals.physiology.org
Asthma is currently recognized as a chronic inflammatory disorder of the airways that leads
to tissue injury and subsequent structural changes collectively called airway remodeling …

[HTML][HTML] The three A's in asthma–airway smooth muscle, airway remodeling & angiogenesis

LF Keglowich, P Borger - The open respiratory medicine journal, 2015 - ncbi.nlm.nih.gov
Asthma affects more than 300 million people worldwide and its prevalence is still rising.
Acute asthma attacks are characterized by severe symptoms such as breathlessness …

Pulmonary vascular changes in asthma and COPD

LM Harkness, V Kanabar, HS Sharma… - Pulmonary …, 2014 - Elsevier
In chronic lung disorders such as in asthma and chronic obstructive pulmonary disease
(COPD) there is increased bronchial angiogenesis and remodelling of pulmonary vessels …

Faster rise of exhaled breath temperature in asthma: a novel marker of airway inflammation?

P Paredi, SA Kharitonov, PJ Barnes - American Journal of …, 2002 - atsjournals.org
In asthma there is increased vascularity of the airway mucosa, altering heat loss in the
airways. We hypothesized that as a result of these inflammatory changes, asthmatic patients …

Genomic and non-genomic actions of glucocorticoids in asthma

AA Alangari - Annals of thoracic medicine, 2010 - journals.lww.com
Glucocorticoids are the mainstay of asthma therapy. They are primarily used to suppress
airway inflammation, which is the central pathological change in asthmatic patients' airways …