The practice of polypharmacology is not a new concept but the approaches which are being
adopted for administering the two or more drugs together are varied from time to time …

The increasing understanding of the role of nitric oxide (NO) in cancer biology has
generated significant progress in the use of NO donor-based therapy to fight cancer. These …

Introduction: The hybridization of biologically active molecules is a powerful tool for drug
discovery used to target a variety of diseases. It offers the prospect of better drugs for the …

Chemotherapy suffers numbers of limitations including poor drug solubility, nonspecific
biodistribution, and inevitable adverse effects on normal tissues. Tumor‐targeted delivery …

Nitric oxide (NO) and its derivatives play important roles in the physiology and
pathophysiology of the liver. Despite its diverse and complicated roles, certain patterns of …

Abstract Oleanolic acid (OA, 3β-hydroxyolean-12-en-28-oic acid) is a ubiquitous pentacyclic
multifunctional triterpenoid, widely found in several dietary and medicinal plants. Natural …

The mercapturic acid pathway is a major route for the biotransformation of xenobiotic and
endobiotic electrophilic compounds and their metabolites. Mercapturic acids (N-acetyl-l …

Natural products (NPs) have played a key role in drug discovery and are still a prolific
source of novel lead compounds or pharmacophores for medicinal chemistry …

Living organisms are continuously exposed to xenobiotics. The major phase of enzymatic
detoxification in many species is the conjugation of activated xenobiotics to reduced …

Silica nanoparticles have emerged as promising candidates in the field of nanomedicine
due to their remarkable versatility and customizable properties. However, concerns about …