In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

The mammalian forebrain is constructed from ensembles of neurons that form local
microcircuits giving rise to the exquisite cognitive tasks the mammalian brain can perform …

Until recently, the study of plasticity of neural circuits focused almost exclusively on
potentiation and depression at excitatory synapses on principal cells. Other elements in the …

Robust incorporation of new principal cells into pre‐existing circuitry in the adult mammalian
brain is unique to the hippocampal dentate gyrus (DG). We asked if adult‐born granule cells …

Long-term potentiation (LTP) of synaptic transmission is a form of activity-dependent
synaptic plasticity that exists at most synapses in the nervous system. In the central nervous …

In the adult mammalian brain, newly generated neurons are continuously incorporated into
two networks: interneurons born in the subventricular zone migrate to the olfactory bulb …

Recent research into local-circuit GABAergic inhibitory interneurons of the mammalian
central nervous system has provided unprecedented insight into the mechanics of neuronal …

Hippocampal GABAergic cells are highly heterogeneous, but the functional significance of
this diversity is not fully understood. By using paired recordings of synaptically connected …

Cortical neuronal network operations depend critically on the recruitment of GABAergic
interneurons and the properties of their inhibitory output signals. Recent evidence indicates …

Schizophrenia may involve hypofunction of NMDA receptor (NMDAR)-mediated signaling,
and alterations in parvalbumin-positive fast-spiking (FS) GABA neurons that may cause …