Importance Mortality among people with opioid dependence is higher than that of the
general population. Opioid agonist treatment (OAT) is an effective treatment for opioid …

An extensive literature on childhood adversity and neurodevelopment has emerged over the
past decade. We evaluate two conceptual models of adversity and neurodevelopment—the …

Life history theory argues that exposure to early life adversity (ELA) accelerates
development, although existing evidence for this varies. We present a meta-analysis and …

Background Childhood is a sensitive period with rapid brain development and physiological
growth, and adverse events in childhood might interfere with these processes and have long …

Background: Childhood trauma (CT) has adverse consequences on mental health across
the lifespan. The understanding of how CT increases vulnerability for psychiatric disorders is …

Early life adversity (ELA) is associated with poorer health in adulthood, an association
explained, at least in part, by increased engagement in health‐risk behaviors (HRBs). In this …

Childhood adversity has been repeatedly and robustly linked to physical and mental illness
across the lifespan. Yet, the biological pathways through which this occurs remain unclear …

This study provides a comprehensive review of the published research on the association
between early life adversity and markers of inflammation in children and adolescents. We …

Importance Childhood adversity (CA) is a powerful determinant of long-term physical and
mental health that is associated with elevated risk for chronic disease and psychopathology …

Importance Adverse childhood experiences (ACEs) are potentially harmful events that occur
during childhood, spanning neglect, physical or sexual abuse, parental separation, or death …