Spectroscopic studies, DFT calculations, cytotoxicity activity, and docking stimulation of novel metal complexes of Schiff base ligand of isonicotinohydrazide derivative
NH Mahmoud, GH Elsayed… - Applied …, 2022 - Wiley Online Library
In this elucidation, the reactivity of isonicotinohydrazide derivative (3)(L) was reacted with
the nitrate salts of Cr (III), Fe (III), Co (II), Ni (II), Cu (II), and Zn (II) to afford the corresponding …
the nitrate salts of Cr (III), Fe (III), Co (II), Ni (II), Cu (II), and Zn (II) to afford the corresponding …
Novel 4-aminoquinolines: Synthesis, inhibition of the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase, antitubercular activity, SAR, and preclinical …
JD Paz, ND de Moura Sperotto, AS Ramos… - European Journal of …, 2023 - Elsevier
Herein a series of 4-aminoquinolines were synthesized in an attempt to optimize and study
the structural features related to LABIO-17 biological activity, a Mycobacterium tuberculosis …
the structural features related to LABIO-17 biological activity, a Mycobacterium tuberculosis …
Aryl-substituted ruthenium (II) complexes: a strategy for enhanced photocleavage and efficient DNA binding
Ruthenium polypyridine complexes have shown promise as agents for photodynamic
therapy (PDT) and tools for molecular biology (chromophore-assisted light inactivation). To …
therapy (PDT) and tools for molecular biology (chromophore-assisted light inactivation). To …
Is IQG-607 a Potential Metallodrug or Metallopro-Drug With a Defined Molecular Target in Mycobacterium tuberculosis?
BL Abbadi, VS Rodrigues-Junior, AS Dadda… - Frontiers in …, 2018 - frontiersin.org
The emergence of strains of Mycobacterium tuberculosis resistant to isoniazid (INH) has
underscored the need for the development of new anti-tuberculosis agents. INH is activated …
underscored the need for the development of new anti-tuberculosis agents. INH is activated …
A bioinorganic chemistry perspective on the roles of metals as drugs and targets against Mycobacterium tuberculosis–a journey of opportunities
Medicinal inorganic chemists have provided many strategies to tackle a myriad of diseases,
pushing forward the frontiers of pharmacology. As an example, the fight against tuberculosis …
pushing forward the frontiers of pharmacology. As an example, the fight against tuberculosis …
A biphosphinic ruthenium complex with potent anti-bacterial and anti-cancer activity
JM da Silveira Carvalho, AH de Morais Batista… - New Journal of …, 2017 - pubs.rsc.org
Metal-based compounds have emerged as a novel strategy to improve our arsenal of
medicines. Among these compounds, carbon monoxide donor agents have been developed …
medicines. Among these compounds, carbon monoxide donor agents have been developed …
Implication of purinergic P2X7 receptor in M. tuberculosis infection and host interaction mechanisms: a mouse model study
AA Santos Jr, V Rodrigues-Junior, RF Zanin, TJ Borges… - Immunobiology, 2013 - Elsevier
In the present study, we analyzed the role of purinergic P2X7 receptor in Mycobacterium
tuberculosis infection and host interaction mechanisms in vitro and in vivo. For experimental …
tuberculosis infection and host interaction mechanisms in vitro and in vivo. For experimental …
Antitubercular activity of Ru (II) isoniazid complexes
I de Aguiar, A Tavares, AC Roveda Jr… - European Journal of …, 2015 - Elsevier
Despite the resistance developed by the Mycobacterium tuberculosis (MTb) strains,
isoniazid (INH) has been recognized as one of the best drug for treatment of Tuberculosis …
isoniazid (INH) has been recognized as one of the best drug for treatment of Tuberculosis …
Light-induced disruption of an acyl hydrazone link as a novel strategy for drug release and activation: isoniazid as a proof-of-concept case
ED Nunes, AD Villela, LA Basso, EH Teixeira… - Inorganic Chemistry …, 2020 - pubs.rsc.org
Aldehydes and acyl hydrazines have been employed in a conjugation reaction that
produces an acyl hydrazone bridge. A drawback to this linkage is hydrolysis, which prevents …
produces an acyl hydrazone bridge. A drawback to this linkage is hydrolysis, which prevents …
Synthesis and mechanistic investigation of iron (II) complexes of isoniazid and derivatives as a redox-mediated activation strategy for anti-tuberculosis therapy
J Laborde, C Deraeve, FG de Mesquita Vieira… - Journal of Inorganic …, 2018 - Elsevier
The emergence of multidrug-resistant strains of Mycobacterium tuberculosis (MTB)
represents a major threat to global health. Isoniazid (INH) is a prodrug used in the first-line …
represents a major threat to global health. Isoniazid (INH) is a prodrug used in the first-line …