The M1/M2 macrophage paradigm plays a key role in tumor progression. M1 macrophages
are historically regarded as anti-tumor, while M2-polarized macrophages, commonly …

Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but
accumulating evidence indicates that inflammation has a critical role in its pathogenesis …

OA is now well accepted as a low-grade inflammatory disease affecting the whole joint. In
addition to mechanical loading, inflammation (particularly synovitis), contributes significantly …

Purpose To use meta-analysis techniques to evaluate the efficacy and safety of platelet-rich
plasma (PRP) injections for the treatment knee of osteoarthritis (OA). Methods We performed …

Effective treatment of osteoarthritis (OA) remains a huge clinical challenge despite major
research efforts. Different tissues and cell-types within the joint contribute to disease …

Osteoarthritis (OA) has long been considered a “wear and tear” disease leading to loss of
cartilage. OA used to be considered the sole consequence of any process leading to …

Abstract Background Knee Osteoarthritis (KOA) is a heterogeneous pathology characterized
by a complex and multifactorial nature. It has been hypothesised that these differences are …

Background: Specific growth factors have been proposed as therapeutic proteins for
cartilage repair. Hypothesis: Platelet-rich plasma (PRP) provides symptomatic relief in early …

Osteoarthritis (OA) has traditionally been classified as a noninflammatory arthritis; however,
the dichotomy between inflammatory and degenerative arthritis is becoming less clear with …

Osteoarthritis (OA), one of the most common rheumatic disorders, is characterized by
cartilage breakdown and by synovial inflammation that is directly linked to clinical symptoms …