Merkel cell carcinoma (MCC) is an aggressive neuroendocrine carcinoma of the skin with
two distinct etiologies. Clonal integration of Merkel cell polyomavirus DNA into the tumor …

Lysine-specific demethylase 1A (LSD1, also named KDM1A) is a demethylase that can
remove methyl groups from histones H3K4me1/2 and H3K9me1/2. It is aberrantly expressed …

The lysine-specific demethylase KDM1A is a key regulator of stem cell potential in acute
myeloid leukemia (AML). ORY-1001 is a highly potent and selective KDM1A inhibitor that …

Transcriptional deregulation initiated by oncogenic fusion proteins plays a vital role in
leukemia. The prevailing view is that the oncogenic fusion protein promyelocytic …

LSD1 was the first histone demethylase identified by Professor Shi Yang and his team
members in 2004. LSD1 employs FAD as its cofactor, which catalyzes the demethylation of …

Acute myeloid leukemia (AML) is a heterogeneous hematopoietic malignancy characterized
by the accumulation of incompletely differentiated progenitor cells (blasts) in the bone …

Drugs that modify the epigenome are powerful tools for treating cancer, but these drugs
often have pleiotropic effects, and identifying patients who will benefit from them remains a …

There is an unmet need to overcome nongenetic therapy-resistance to improve outcomes in
AML, especially post-myeloproliferative neoplasm (MPN) secondary (s) AML. Studies …

Acute myeloid leukemia (AML) is a clonal disorder of myeloid progenitors characterized by
the acquisition of chromosomal abnormalities, somatic mutations, and epigenetic changes …

Dually targeting the epigenetic proteins lysine specific demethylase 1 (LSD1) and histone
deacetylases (HDACs) that play a key role in cancer cells by modulating gene repressor …