Precision Medicine implies a deep understanding of inter-individual differences in health
and disease that are due to genetic and environmental factors. To acquire such …

Artificial intelligence (AI) and nanotechnology are two fields that are instrumental in realizing
the goal of precision medicine—tailoring the best treatment for each cancer patient. Recent …

Women experience adverse drug reactions, ADRs, nearly twice as often as men, yet the role
of sex as a biological factor in the generation of ADRs is poorly understood. Most drugs …

Sex and gender differences impact the incidence of SARS-CoV-2 infection and COVID-19
mortality. Furthermore, sex differences influence the frequency and severity of …

Disclaimer: Due to the rapidly evolving nature of this outbreak, and in the interests of rapid
dissemination of reliable, actionable information, this paper went through expedited peer …

In humans, the combination of all sex-specific genetic, epigenetic, and hormonal influences
of biologic sex produces different in vivo environments for male and female cells. We dissect …

In the vast majority of cardiovascular diseases (CVDs), there are well-described differences
between women and men in epidemiology, pathophysiology, clinical manifestations, effects …

Polypharmacy is very common in older adults and increases the risk of inappropriate and
unsafe prescribing for older adults. Older adults, particularly women (who make up the …

Drug survival reflects a drug's effectiveness, safety, and tolerability. We assessed the drug
survival of biologics used to treat psoriasis in a prospective national pharmacovigilance …

Abstract In May 2014, the National Institutes of Health (NIH) stated its intent to “require
applicants to consider sex as a biological variable (SABV) in the design and analysis of NIH …