Owing to their outstanding performances in molecular recognition, antibodies are
extensively used in research and applications in molecular biology, biotechnology and …

One of the major functions of the protein homeostasis system is to maintain proteins in their
soluble states, and indeed several human disorders are associated with the aberrant …

Biologics, such as antibodies and enzymes, are crucial in research, biotechnology,
diagnostics, and therapeutics. Often, biologics with suitable functionality are discovered, but …

Although antibodies have become the fastest-growing class of therapeutics on the market, it
is still challenging to develop them for therapeutic applications, which often require these …

Transforming growth factor-β-induced protein (TGFBIp), an extracellular matrix protein, is the
second most abundant protein in the corneal stroma. In this review, we summarize the …

The human cornea is responsible for approximately 70% of the eye's optical power and,
together with the lens, constitutes the only transparent tissue in the human body. Low …

Purpose To provide a brief summary and comparison of the most recent literature on
available and theorized treatment modalities for classic lattice corneal dystrophy (LCD). This …

Protein aggregation has been one of the leading triggers of various disease conditions, such
as Alzheimer's, Parkinson's and other amyloidosis. TGFBI-associated corneal dystrophies …

The ability of proteins to aggregate to form well-organized β-sheet rich amyloid fibrils is
increasingly viewed as a general if regrettable property of the polypeptide chain …

Corneal dystrophies are a group of genetically inherited disorders with mutations in the
TGFBI gene affecting the Bowman's membrane and the corneal stroma. The mutant TGFBIp …