Proteases: multifunctional enzymes in life and disease
C López-Otín, JS Bond - Journal of Biological Chemistry, 2008 - ASBMB
October 1, 1905 (1). Today, after more than 100 years and 350,000 articles on these
enzymes in the scientific literature, proteases remain at the cutting edge of biological …
enzymes in the scientific literature, proteases remain at the cutting edge of biological …
Unleashing the therapeutic potential of human kallikrein-related serine proteases
Tissue kallikreins are a family of fifteen secreted serine proteases encoded by the largest
protease gene cluster in the human genome. In the past decade, substantial progress has …
protease gene cluster in the human genome. In the past decade, substantial progress has …
Current insights into the metastasis of epithelial ovarian cancer-hopes and hurdles
Background Ovarian cancer is the most lethal gynecologic cancer and the fifth leading
cause of cancer-related mortality in women worldwide. Despite various attempts to improve …
cause of cancer-related mortality in women worldwide. Despite various attempts to improve …
Biomarkers for prostate cancer detection and risk stratification
Although prostate cancer (PCa) is the most commonly diagnosed cancer in men, most
patients do not die from the disease. Prostate specific antigen (PSA), the most widely used …
patients do not die from the disease. Prostate specific antigen (PSA), the most widely used …
Beyond the biomarker role: prostate-specific antigen (PSA) in the prostate cancer microenvironment
The prostate-specific antigen (PSA) blood test is the accepted biomarker of tumor
recurrence. PSA levels in serum correlate with disease progression, though its diagnostic …
recurrence. PSA levels in serum correlate with disease progression, though its diagnostic …
Sexual conflict and seminal fluid proteins: a dynamic landscape of sexual interactions
Sexual reproduction requires coordinated contributions from both sexes to proceed
efficiently. However, the reproductive strategies that the sexes adopt often have the potential …
efficiently. However, the reproductive strategies that the sexes adopt often have the potential …
Functional roles of human kallikrein-related peptidases
G Sotiropoulou, G Pampalakis… - Journal of Biological …, 2009 - ASBMB
Kallikrein-related peptidases constitute a single family of 15 (chymo) trypsin-like proteases
(KLK1–15) with pleiotropic physiological roles. Aberrant regulation of KLKs has been …
(KLK1–15) with pleiotropic physiological roles. Aberrant regulation of KLKs has been …
Network analyses reveal pervasive functional regulation between proteases in the human protease web
Proteolytic processing is an irreversible posttranslational modification affecting a large
portion of the proteome. Protease-cleaved mediators frequently exhibit altered activity, and …
portion of the proteome. Protease-cleaved mediators frequently exhibit altered activity, and …
The tumor proteolytic landscape: a challenging frontier in cancer diagnosis and therapy
M Vizovisek, D Ristanovic, S Menghini… - International journal of …, 2021 - mdpi.com
In recent decades, dysregulation of proteases and atypical proteolysis have become
increasingly recognized as important hallmarks of cancer, driving community-wide efforts to …
increasingly recognized as important hallmarks of cancer, driving community-wide efforts to …
Integrated 3D view of postmating responses by the Drosophila melanogaster female reproductive tract, obtained by micro-computed tomography scanning
Physiological changes in females during and after mating are triggered by seminal fluid
components in conjunction with female-derived molecules. In insects, these changes …
components in conjunction with female-derived molecules. In insects, these changes …