A hallmark event in neurodegenerative diseases (NDs) is the misfolding, aggregation, and
accumulation of proteins, leading to cellular dysfunction, loss of synaptic connections, and …

The medial prefrontal cortex (mPFC) is a crucial cortical region that integrates information
from numerous cortical and subcortical areas and converges updated information to output …

Parkinson's disease (PD) is a common neurodegenerative disorder primarily caused by the
death of dopaminergic neurons in the substantia nigra pars compacta (SNpc). However, the …

It is reasonably well established that prior to the motor phase of classical Parkinson's
disease (PD) there is a prodromal period of several years duration. Once typical motor …

Background: Physical activity (PA) is increasingly advocated as an adjunct intervention for
individuals with Parkinson's disease (PD). However, the specific benefits of PA on the wide …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

Abstract Objective People with Parkinson disease (PD) frequently develop dementia, which
is associated with neocortical deposition of alpha‐synuclein (α‐syn) in Lewy bodies and …

Neurotransmitters and neuromodulators, such as dopamine, participate in a wide range of
behavioral and cognitive functions in the adult brain, including movement, cognition, and …

The motor manifestations of Parkinson's disease (PD) have been linked to an abnormal
spatial covariance pattern involving basal ganglia thalamocortical pathways. By contrast …

To provide evidence‐based recommendations for the management of late (complicated)
Parkinson's disease (PD), based on a review of the literature. Complicated PD refers to …