Adipose tissue influences tumor development in two major ways. First, obese individuals
have a higher risk of developing certain cancers (endometrial, esophageal, and renal cell …

Obesity increases the risk of cardiovascular disease and premature death. Adipose tissue
releases a large number of bioactive mediators that influence not only body weight …

Obesity plays a causative role in the pathogenesis of the metabolic syndrome. Adipokines
may link obesity to its co-morbidities. Most adipokines with pro-inflammatory properties are …

Mounting evidence highlights the role of adipose tissue in the development of a systemic
inflammatory state that contributes to obesity-associated vasculopathy and cardiovascular …

Uric acid, despite being a major antioxidant in the human plasma, both correlates and
predicts development of obesity, hypertension, and cardiovascular disease, conditions …

Adipose tissue, when carried around in excessive amounts, predisposes to a large number
of diseases. Epidemiological data show that the prevalence of obesity has significantly …

Objective—Weight gain is associated with infiltration of fat by macrophages, suggesting that
they are an important source of inflammation in obese adipose tissue. Here we developed …

Dyslipidemia and insulin resistance are commonly associated with catabolic or
lipodystrophic conditions (such as cancer and sepsis) and with pathological states of …

Uric acid is considered a major antioxidant in human blood that may protect against aging
and oxidative stress. Despite its proposed protective properties, elevated levels of uric acid …

Compelling evidence supports the concepts that gut microbiota actively promotes weight
gain and fat accumulation and sustains, indirectly, a condition of low-grade inflammation …