Joint distraction, the prolonged mechanical separation of the bones at a joint, has emerged
as a joint-preserving treatment for end-stage osteoarthritis, with the gradually growing …

Objective To summarize recent scientific advances in protein-derived soluble biomarkers of
osteoarthritis. Design A systematic search on the PubMed electronic database of clinical …

Despite an increasing burden of osteoarthritis in developed societies, target discovery has
been slow and there are currently no approved disease-modifying osteoarthritis drugs. This …

Objective The aim of this systematic review was to analyze the evidence about the efficacy of
the several synovial fluid (SF) biomarkers proposed for knee osteoarthritis (OA), categorizing …

During the development of the appendicular skeleton, the cartilaginous templates undergo
hypertrophic differentiation and remodels into bone, except for the cartilage most adjacent to …

Osteoarthritis (OA) is the most prevalent chronic joint disease, with physical exercise being a
widely endorsed strategy in its management guidelines. Exerkines, defined as cytokines …

Background: The disruption of joint homeostasis is a critical event during the process of joint
injury in osteoarthritis (OA). As regulatory molecules, microRNAs (miRNAs) can be released …

Objectives Knee joint distraction (KJD) has been shown to result in long-term clinical
improvement and short-term cartilage restoration in young OA patients. The objective of the …

Purpose The purpose of this study was to:(1) test the hypothesis that HTO improves articular
cartilage composition in the medial compartment without adversely affecting the lateral …

Objective Although mechanically-induced inflammation is an appealing explanation linking
different etiologic factors in osteoarthritis (OA), clinical research investigating changes in …