Cofilin and actin dynamics: multiple modes of regulation and their impacts in neuronal development and degeneration

JR Bamburg, LS Minamide, ON Wiggan… - Cells, 2021 - mdpi.com
Proteins of the actin depolymerizing factor (ADF)/cofilin family are ubiquitous among
eukaryotes and are essential regulators of actin dynamics and function. Mammalian neurons …

Mechanisms of actin disassembly and turnover

BL Goode, J Eskin, S Shekhar - Journal of Cell Biology, 2023 - rupress.org
Cellular actin networks exhibit a wide range of sizes, shapes, and architectures tailored to
their biological roles. Once assembled, these filamentous networks are either maintained in …

Actin and endocytosis in budding yeast

BL Goode, JA Eskin, B Wendland - Genetics, 2015 - academic.oup.com
Endocytosis, the process whereby the plasma membrane invaginates to form vesicles, is
essential for bringing many substances into the cell and for membrane turnover. The …

Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin

T Kotila, H Wioland, G Enkavi, K Kogan… - Nature …, 2019 - nature.com
The ability of cells to generate forces through actin filament turnover was an early adaptation
in evolution. While much is known about how actin filaments grow, mechanisms of their …

Actomyosin-driven division of a synthetic cell

L Baldauf, L Van Buren, F Fanalista… - ACS Synthetic …, 2022 - ACS Publications
One of the major challenges of bottom-up synthetic biology is rebuilding a minimal cell
division machinery. From a reconstitution perspective, the animal cell division apparatus is …

Extensive identification of genes involved in congenital and structural heart disorders and cardiomyopathy

N Spielmann, G Miller, TI Oprea, CW Hsu… - Nature Cardiovascular …, 2022 - nature.com
Clinical presentation of congenital heart disease is heterogeneous, making identification of
the disease-causing genes and their genetic pathways and mechanisms of action …

The role of ADF/cofilin in synaptic physiology and Alzheimer's disease

Y Ben Zablah, N Merovitch, Z Jia - Frontiers in Cell and …, 2020 - frontiersin.org
Actin-depolymerization factor (ADF)/cofilin, a family of actin-binding proteins, are critical for
the regulation of actin reorganization in response to various signals. Accumulating evidence …

High-speed depolymerization at actin filament ends jointly catalysed by Twinfilin and Srv2/CAP

AB Johnston, A Collins, BL Goode - Nature cell biology, 2015 - nature.com
Purified actin filaments depolymerize slowly, and cytosolic conditions strongly favour actin
assembly over disassembly, which has left our understanding of how actin filaments are …

CASEIN KINASE1-LIKE PROTEIN2 regulates actin filament stability and stomatal closure via phosphorylation of actin depolymerizing factor

S Zhao, Y Jiang, Y Zhao, S Huang, M Yuan… - The Plant …, 2016 - academic.oup.com
The opening and closing of stomata are crucial for plant photosynthesis and transpiration.
Actin filaments undergo dynamic reorganization during stomatal closure, but the underlying …

Single-molecule imaging of a three-component ordered actin disassembly mechanism

S Jansen, A Collins, SM Chin, CA Ydenberg… - Nature …, 2015 - nature.com
The mechanisms by which cells destabilize and rapidly disassemble filamentous actin
networks have remained elusive; however, Coronin, Cofilin and AIP1 have been implicated …