Cofilin and actin dynamics: multiple modes of regulation and their impacts in neuronal development and degeneration
JR Bamburg, LS Minamide, ON Wiggan… - Cells, 2021 - mdpi.com
Proteins of the actin depolymerizing factor (ADF)/cofilin family are ubiquitous among
eukaryotes and are essential regulators of actin dynamics and function. Mammalian neurons …
eukaryotes and are essential regulators of actin dynamics and function. Mammalian neurons …
Mechanisms of actin disassembly and turnover
Cellular actin networks exhibit a wide range of sizes, shapes, and architectures tailored to
their biological roles. Once assembled, these filamentous networks are either maintained in …
their biological roles. Once assembled, these filamentous networks are either maintained in …
Actin and endocytosis in budding yeast
BL Goode, JA Eskin, B Wendland - Genetics, 2015 - academic.oup.com
Endocytosis, the process whereby the plasma membrane invaginates to form vesicles, is
essential for bringing many substances into the cell and for membrane turnover. The …
essential for bringing many substances into the cell and for membrane turnover. The …
Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin
The ability of cells to generate forces through actin filament turnover was an early adaptation
in evolution. While much is known about how actin filaments grow, mechanisms of their …
in evolution. While much is known about how actin filaments grow, mechanisms of their …
Actomyosin-driven division of a synthetic cell
One of the major challenges of bottom-up synthetic biology is rebuilding a minimal cell
division machinery. From a reconstitution perspective, the animal cell division apparatus is …
division machinery. From a reconstitution perspective, the animal cell division apparatus is …
Extensive identification of genes involved in congenital and structural heart disorders and cardiomyopathy
Clinical presentation of congenital heart disease is heterogeneous, making identification of
the disease-causing genes and their genetic pathways and mechanisms of action …
the disease-causing genes and their genetic pathways and mechanisms of action …
The role of ADF/cofilin in synaptic physiology and Alzheimer's disease
Y Ben Zablah, N Merovitch, Z Jia - Frontiers in Cell and …, 2020 - frontiersin.org
Actin-depolymerization factor (ADF)/cofilin, a family of actin-binding proteins, are critical for
the regulation of actin reorganization in response to various signals. Accumulating evidence …
the regulation of actin reorganization in response to various signals. Accumulating evidence …
High-speed depolymerization at actin filament ends jointly catalysed by Twinfilin and Srv2/CAP
AB Johnston, A Collins, BL Goode - Nature cell biology, 2015 - nature.com
Purified actin filaments depolymerize slowly, and cytosolic conditions strongly favour actin
assembly over disassembly, which has left our understanding of how actin filaments are …
assembly over disassembly, which has left our understanding of how actin filaments are …
CASEIN KINASE1-LIKE PROTEIN2 regulates actin filament stability and stomatal closure via phosphorylation of actin depolymerizing factor
The opening and closing of stomata are crucial for plant photosynthesis and transpiration.
Actin filaments undergo dynamic reorganization during stomatal closure, but the underlying …
Actin filaments undergo dynamic reorganization during stomatal closure, but the underlying …
Single-molecule imaging of a three-component ordered actin disassembly mechanism
S Jansen, A Collins, SM Chin, CA Ydenberg… - Nature …, 2015 - nature.com
The mechanisms by which cells destabilize and rapidly disassemble filamentous actin
networks have remained elusive; however, Coronin, Cofilin and AIP1 have been implicated …
networks have remained elusive; however, Coronin, Cofilin and AIP1 have been implicated …