Biophysical and biochemical cues of biomaterials guide mesenchymal stem cell behaviors

J Li, Y Liu, Y Zhang, B Yao, Enhejirigala, Z Li… - Frontiers in Cell and …, 2021 - frontiersin.org
Mesenchymal stem cells (MSCs) have been widely used in the fields of tissue engineering
and regenerative medicine due to their self-renewal capabilities and multipotential …

Emergence of synthetic mRNA: In vitro synthesis of mRNA and its applications in regenerative medicine

H Kwon, M Kim, Y Seo, YS Moon, HJ Lee, K Lee, H Lee - Biomaterials, 2018 - Elsevier
The field of gene therapy has evolved over the past two decades after the first introduction of
nucleic acid drugs, such as plasmid DNA (pDNA). With the development of in vitro …

Separable microneedle patch to protect and deliver DNA nanovaccines against COVID-19

Y Yin, W Su, J Zhang, W Huang, X Li, H Ma, M Tan… - ACS …, 2021 - ACS Publications
The successful control of coronavirus disease 2019 (COVID-19) pandemic is not only relying
on the development of vaccines, but also depending on the storage, transportation, and …

Theranostic cells: emerging clinical applications of synthetic biology

MP McNerney, KE Doiron, TL Ng, TZ Chang… - Nature Reviews …, 2021 - nature.com
Synthetic biology seeks to redesign biological systems to perform novel functions in a
predictable manner. Recent advances in bacterial and mammalian cell engineering include …

A microneedle-based delivery system for broad-protection seasonal influenza A DNA nanovaccines

L Wang, L Yang, F Zhang, X Liu, Q Xie, Q Liu… - Cell Reports Physical …, 2023 - cell.com
Seasonal influenza A viruses continue to pose a public health threat, and current vaccines
are not sufficiently effective because of virus mutation. There is an urgent need to develop a …

Long noncoding RNA H19 upregulates vascular endothelial growth factor A to enhance mesenchymal stem cells survival and angiogenic capacity by inhibiting miR …

J Hou, L Wang, Q Wu, G Zheng, H Long, H Wu… - Stem Cell Research & …, 2018 - Springer
Background Currently, the overall therapeutic efficiency of mesenchymal stem cells (MSCs)
transplantation for the treatment of cardiovascular disease is not satisfactory. The low …

Recent progress in stem cell modification for cardiac regeneration

H Lemcke, N Voronina, G Steinhoff… - Stem Cells …, 2018 - Wiley Online Library
During the past decades, stem cell‐based therapy has acquired a promising role in
regenerative medicine. The application of novel cell therapeutics for the treatment of …

Toward regeneration of the heart: bioengineering strategies for immunomodulation

A Ferrini, MM Stevens, S Sattler… - Frontiers in …, 2019 - frontiersin.org
Myocardial Infarction (MI) is the most common cardiovascular disease. An average-sized MI
causes the loss of up to 1 billion cardiomyocytes and the adult heart lacks the capacity to …

Chitosan/calcium silicate cardiac patch stimulates cardiomyocyte activity and myocardial performance after infarction by synergistic effect of bioactive ions and aligned …

X Wang, L Wang, Q Wu, F Bao, H Yang… - … applied materials & …, 2018 - ACS Publications
Cardiac tissue engineering (CTE) remains a great challenge to construct a cell-inductive
scaffold that has positive effects on cardiac cell behaviors and cardiac tissue repair. In this …

Functionally improved mesenchymal stem cells to better treat myocardial infarction

Z Chen, L Chen, C Zeng, WE Wang - Stem cells international, 2018 - Wiley Online Library
Myocardial infarction (MI) is one of the leading causes of death worldwide. Mesenchymal
stem cell (MSC) transplantation is considered a promising approach and has made …