Cannabidiol (CBD) is an abundant non‐psychoactive phytocannabinoid in cannabis
extracts which has high affinity on a series of receptors, including Type 1 cannabinoid …

The development of alcohol use disorder (AUD) involves binge or heavy drinking to high
levels of intoxication that leads to compulsive intake, the loss of control in limiting intake, and …

Hypoxia-inducible factor pathway genes are linked to adaptation in both human and
nonhuman highland species. EPAS1, a notable target of hypoxia adaptation, is associated …

Exposure to stress is an undeniable, but in most cases surmountable, part of life. However,
in certain individuals, exposure to severe or cumulative stressors can lead to an array of …

Cannabinoids, including the two main phytocannabinoids Δ 9-tetrahydrocannabinol (THC)
and cannabidiol (CBD), are being increasingly utilised as pharmacological interventions for …

Sleep is a vital function of the nervous system that contributes to brain and bodily
homeostasis, energy levels, cognitive ability, and other key functions of a variety of …

Background Cannabis is one of the most widely used drugs worldwide. Cannabis use
disorder is characterised by recurrent use of cannabis that causes significant clinical and …

The neurobiology of sleep and substance abuse interconnects, such that alterations in one
process have consequences for the other. Acute exposure to drugs of abuse disrupts sleep …

In older persons, sleep complaints in the form of insomnia and daytime drowsiness are
highly prevalent and are associated with adverse outcomes. The underlying mechanisms …

These experiments aimed to assess whether enhanced activity at the cannabinoid CB1
receptor elicits antidepressant-like effects. To examine this we administered 1 and 5 mg/kg …