High-throughput automation in chemical process development
JA Selekman, J Qiu, K Tran, J Stevens… - Annual review of …, 2017 - annualreviews.org
High-throughput (HT) techniques built upon laboratory automation technology and coupled
to statistical experimental design and parallel experimentation have enabled the …
to statistical experimental design and parallel experimentation have enabled the …
Nanomole-scale high-throughput chemistry for the synthesis of complex molecules
A Buitrago Santanilla, EL Regalado, T Pereira… - Science, 2015 - science.org
At the forefront of new synthetic endeavors, such as drug discovery or natural product
synthesis, large quantities of material are rarely available and timelines are tight. A …
synthesis, large quantities of material are rarely available and timelines are tight. A …
Quantum harmonic oscillator state synthesis by reservoir engineering
D Kienzler, HY Lo, B Keitch, L De Clercq, F Leupold… - Science, 2015 - science.org
The robust generation of quantum states in the presence of decoherence is a primary
challenge for explorations of quantum mechanics at larger scales. Using the mechanical …
challenge for explorations of quantum mechanics at larger scales. Using the mechanical …
Self‐optimizing reactor systems: algorithms, on‐line analytics, setups, and strategies for accelerating continuous flow process optimization
This review provides an overview of recent developments in the area of continuous flow
process optimization by employing self‐optimizing reactor systems. Although only few …
process optimization by employing self‐optimizing reactor systems. Although only few …
Precise control of process parameters for> 23% efficiency perovskite solar cells in ambient air using an automated device acceleration platform
Achieving high-performance perovskite photovoltaics, especially in ambient air, is critically
dependent on the precise optimization of process parameters. However, traditional manual …
dependent on the precise optimization of process parameters. However, traditional manual …
Autonomous optimization of an organic solar cell in a 4-dimensional parameter space
T Osterrieder, F Schmitt, L Lüer, J Wagner… - Energy & …, 2023 - pubs.rsc.org
Optimizing solution-processed organic solar cells is a complex and challenging task due to
the vast parameter space in organic photovoltaics (OPV). Classical Edisonian or one …
the vast parameter space in organic photovoltaics (OPV). Classical Edisonian or one …
End-to-End Automated Synthesis of C(sp3)-Enriched Drug-like Molecules via Negishi Coupling and Novel, Automated Liquid–Liquid Extraction
I Abdiaj, S Cañellas, A Dieguez… - Journal of medicinal …, 2022 - ACS Publications
Herein, we report an end-to-end process including synthesis, work-up, purification, and post-
purification with minimal human intervention using Negishi coupling as a key transformation …
purification with minimal human intervention using Negishi coupling as a key transformation …
Discovery of a 3-(4-pyrimidinyl) indazole (MLi-2), an orally available and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor that reduces brain kinase activity
JD Scott, DE DeMong, TJ Greshock… - Journal of medicinal …, 2017 - ACS Publications
Leucine-rich repeat kinase 2 (LRRK2) is a large, multidomain protein which contains a
kinase domain and GTPase domain among other regions. Individuals possessing gain of …
kinase domain and GTPase domain among other regions. Individuals possessing gain of …
Fully automated chemical synthesis: toward the universal synthesizer
N Collins, D Stout, JP Lim, JP Malerich… - … Process Research & …, 2020 - ACS Publications
Automated peptide and oligonucleotide synthesizers enabled a revolution in molecular
biology and helped pave the way to modern synthetic biology. Similarly, fully automated …
biology and helped pave the way to modern synthetic biology. Similarly, fully automated …
Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole …
T Cernak, NJ Gesmundo, K Dykstra, Y Yu… - Journal of Medicinal …, 2017 - ACS Publications
Miniaturization and parallel processing play an important role in the evolution of many
technologies. We demonstrate the application of miniaturized high-throughput …
technologies. We demonstrate the application of miniaturized high-throughput …