High-throughput automation in chemical process development

JA Selekman, J Qiu, K Tran, J Stevens… - Annual review of …, 2017 - annualreviews.org
High-throughput (HT) techniques built upon laboratory automation technology and coupled
to statistical experimental design and parallel experimentation have enabled the …

Nanomole-scale high-throughput chemistry for the synthesis of complex molecules

A Buitrago Santanilla, EL Regalado, T Pereira… - Science, 2015 - science.org
At the forefront of new synthetic endeavors, such as drug discovery or natural product
synthesis, large quantities of material are rarely available and timelines are tight. A …

Quantum harmonic oscillator state synthesis by reservoir engineering

D Kienzler, HY Lo, B Keitch, L De Clercq, F Leupold… - Science, 2015 - science.org
The robust generation of quantum states in the presence of decoherence is a primary
challenge for explorations of quantum mechanics at larger scales. Using the mechanical …

Self‐optimizing reactor systems: algorithms, on‐line analytics, setups, and strategies for accelerating continuous flow process optimization

DC Fabry, E Sugiono, M Rueping - Israel Journal of Chemistry, 2014 - Wiley Online Library
This review provides an overview of recent developments in the area of continuous flow
process optimization by employing self‐optimizing reactor systems. Although only few …

Precise control of process parameters for> 23% efficiency perovskite solar cells in ambient air using an automated device acceleration platform

J Zhang, J Wu, A Barabash, T Du, S Qiu… - Energy & …, 2024 - pubs.rsc.org
Achieving high-performance perovskite photovoltaics, especially in ambient air, is critically
dependent on the precise optimization of process parameters. However, traditional manual …

Autonomous optimization of an organic solar cell in a 4-dimensional parameter space

T Osterrieder, F Schmitt, L Lüer, J Wagner… - Energy & …, 2023 - pubs.rsc.org
Optimizing solution-processed organic solar cells is a complex and challenging task due to
the vast parameter space in organic photovoltaics (OPV). Classical Edisonian or one …

End-to-End Automated Synthesis of C(sp3)-Enriched Drug-like Molecules via Negishi Coupling and Novel, Automated Liquid–Liquid Extraction

I Abdiaj, S Cañellas, A Dieguez… - Journal of medicinal …, 2022 - ACS Publications
Herein, we report an end-to-end process including synthesis, work-up, purification, and post-
purification with minimal human intervention using Negishi coupling as a key transformation …

Discovery of a 3-(4-pyrimidinyl) indazole (MLi-2), an orally available and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor that reduces brain kinase activity

JD Scott, DE DeMong, TJ Greshock… - Journal of medicinal …, 2017 - ACS Publications
Leucine-rich repeat kinase 2 (LRRK2) is a large, multidomain protein which contains a
kinase domain and GTPase domain among other regions. Individuals possessing gain of …

Fully automated chemical synthesis: toward the universal synthesizer

N Collins, D Stout, JP Lim, JP Malerich… - … Process Research & …, 2020 - ACS Publications
Automated peptide and oligonucleotide synthesizers enabled a revolution in molecular
biology and helped pave the way to modern synthetic biology. Similarly, fully automated …

Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole …

T Cernak, NJ Gesmundo, K Dykstra, Y Yu… - Journal of Medicinal …, 2017 - ACS Publications
Miniaturization and parallel processing play an important role in the evolution of many
technologies. We demonstrate the application of miniaturized high-throughput …