Since the 1960s, methicillin-resistant Staphylococcus aureus (MRSA) has emerged,
disseminated globally and become a leading cause of bacterial infections in both health …

Clinical microbiology has long relied on growing bacteria in culture to determine
antimicrobial susceptibility profiles, but the use of whole-genome sequencing for antibiotic …

Anaemia is a global public health concern, afflicting adolescent girls, women of reproductive
age, pregnant women and children in low-and middle-income countries. 1 Reduction of …

Public health interventions to control the current epidemic of carbapenem-resistant
Klebsiella pneumoniae rely on a comprehensive understanding of its emergence and …

Visualization is frequently used to aid our interpretation of complex datasets. Within
microbial genomics, visualizing the relationships between multiple genomes as a tree …

Current molecular diagnostics of human pathogens provide limited information that is often
not sufficient for outbreak and transmission investigation. Next generation sequencing …

Outbreaks of multidrug-resistant bacteria present a frequent threat to vulnerable patient
populations in hospitals around the world. Intensive care unit (ICU) patients are particularly …

The routine use of genomics for disease surveillance provides the opportunity for high-
resolution bacterial epidemiology. Current whole-genome clustering and multilocus typing …

Background The spread of drug-resistant bacterial pathogens poses a major threat to global
health. It is widely recognised that the widespread use of antibiotics has generated selective …

Molecular and genomic surveillance systems for bacterial pathogens currently rely on
tracking clonally evolving lineages. By contrast, plasmids are usually excluded or analyzed …