Age-associated epigenetic changes in mammalian sperm: implications for offspring health and development
V Ashapkin, A Suvorov, JR Pilsner… - Human reproduction …, 2023 - academic.oup.com
BACKGROUND Modern reproductive behavior in most developed countries is characterized
by delayed parenthood. Older gametes are generally less fertile, accumulating and …
by delayed parenthood. Older gametes are generally less fertile, accumulating and …
Heavy metal and metalloid-induced reproductive toxicity
Heavy metals and metalloid exposure are among the most common factors responsible for
reproductive toxicity in human beings. Several studies have indicated that numerous metals …
reproductive toxicity in human beings. Several studies have indicated that numerous metals …
[HTML][HTML] Obesity and bariatric surgery drive epigenetic variation of spermatozoa in humans
Obesity is a heritable disorder, with children of obese fathers at higher risk of developing
obesity. Environmental factors epigenetically influence somatic tissues, but the contribution …
obesity. Environmental factors epigenetically influence somatic tissues, but the contribution …
Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice
Small non-coding RNAs (sncRNAs) are potential vectors at the interface between genes and
environment. We found that traumatic stress in early life altered mouse microRNA (miRNA) …
environment. We found that traumatic stress in early life altered mouse microRNA (miRNA) …
[HTML][HTML] Sperm epigenetics and influence of environmental factors
Background Developmental programming of the embryo is controlled by genetic information
but also dictated by epigenetic information contained in spermatozoa. Lifestyle and …
but also dictated by epigenetic information contained in spermatozoa. Lifestyle and …
[HTML][HTML] Obesity, male infertility, and the sperm epigenome
JR Craig, TG Jenkins, DT Carrell, JM Hotaling - Fertility and sterility, 2017 - Elsevier
Obesity is a growing epidemic and a common problem among reproductive-age men that
can both cause and exacerbate male-factor infertility by means of endocrine abnormalities …
can both cause and exacerbate male-factor infertility by means of endocrine abnormalities …
[HTML][HTML] High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring
T de Castro Barbosa, LR Ingerslev, PS Alm… - Molecular …, 2016 - Elsevier
Objectives Chronic and high consumption of fat constitutes an environmental stress that
leads to metabolic diseases. We hypothesized that high-fat diet (HFD) transgenerationally …
leads to metabolic diseases. We hypothesized that high-fat diet (HFD) transgenerationally …
[HTML][HTML] Unraveling the harmful effect of oxidative stress on male fertility: A mechanistic insight
T Hussain, M Kandeel, E Metwally, G Murtaza… - Frontiers in …, 2023 - frontiersin.org
Male infertility is a widely debated issue that affects males globally. There are several
mechanisms involved. Oxidative stress is accepted to be the main contributing factor, with …
mechanisms involved. Oxidative stress is accepted to be the main contributing factor, with …
Impact of obesity on male fertility, sperm function and molecular composition
Male obesity in reproductive-age men has nearly tripled in the past 30 y and coincides with
an increase in male infertility worldwide. There is now emerging evidence that male obesity …
an increase in male infertility worldwide. There is now emerging evidence that male obesity …
Parental advisory: maternal and paternal stress can impact offspring neurodevelopment
Parental stress exposures are implicated in the risk for offspring neurodevelopmental and
neuropsychiatric disorders, prompting critical examination of preconception and prenatal …
neuropsychiatric disorders, prompting critical examination of preconception and prenatal …