Age-associated epigenetic changes in mammalian sperm: implications for offspring health and development

V Ashapkin, A Suvorov, JR Pilsner… - Human reproduction …, 2023 - academic.oup.com
BACKGROUND Modern reproductive behavior in most developed countries is characterized
by delayed parenthood. Older gametes are generally less fertile, accumulating and …

Heavy metal and metalloid-induced reproductive toxicity

AG Mukherjee, UR Wanjari, K Renu, B Vellingiri… - Environmental …, 2022 - Elsevier
Heavy metals and metalloid exposure are among the most common factors responsible for
reproductive toxicity in human beings. Several studies have indicated that numerous metals …

[HTML][HTML] Obesity and bariatric surgery drive epigenetic variation of spermatozoa in humans

I Donkin, S Versteyhe, LR Ingerslev, K Qian, M Mechta… - Cell metabolism, 2016 - cell.com
Obesity is a heritable disorder, with children of obese fathers at higher risk of developing
obesity. Environmental factors epigenetically influence somatic tissues, but the contribution …

Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice

K Gapp, A Jawaid, P Sarkies, J Bohacek… - Nature …, 2014 - nature.com
Small non-coding RNAs (sncRNAs) are potential vectors at the interface between genes and
environment. We found that traumatic stress in early life altered mouse microRNA (miRNA) …

[HTML][HTML] Sperm epigenetics and influence of environmental factors

I Donkin, R Barrès - Molecular metabolism, 2018 - Elsevier
Background Developmental programming of the embryo is controlled by genetic information
but also dictated by epigenetic information contained in spermatozoa. Lifestyle and …

[HTML][HTML] Obesity, male infertility, and the sperm epigenome

JR Craig, TG Jenkins, DT Carrell, JM Hotaling - Fertility and sterility, 2017 - Elsevier
Obesity is a growing epidemic and a common problem among reproductive-age men that
can both cause and exacerbate male-factor infertility by means of endocrine abnormalities …

[HTML][HTML] High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring

T de Castro Barbosa, LR Ingerslev, PS Alm… - Molecular …, 2016 - Elsevier
Objectives Chronic and high consumption of fat constitutes an environmental stress that
leads to metabolic diseases. We hypothesized that high-fat diet (HFD) transgenerationally …

[HTML][HTML] Unraveling the harmful effect of oxidative stress on male fertility: A mechanistic insight

T Hussain, M Kandeel, E Metwally, G Murtaza… - Frontiers in …, 2023 - frontiersin.org
Male infertility is a widely debated issue that affects males globally. There are several
mechanisms involved. Oxidative stress is accepted to be the main contributing factor, with …

Impact of obesity on male fertility, sperm function and molecular composition

NO Palmer, HW Bakos, T Fullston, M Lane - Spermatogenesis, 2012 - Taylor & Francis
Male obesity in reproductive-age men has nearly tripled in the past 30 y and coincides with
an increase in male infertility worldwide. There is now emerging evidence that male obesity …

Parental advisory: maternal and paternal stress can impact offspring neurodevelopment

JC Chan, BM Nugent, TL Bale - Biological psychiatry, 2018 - Elsevier
Parental stress exposures are implicated in the risk for offspring neurodevelopmental and
neuropsychiatric disorders, prompting critical examination of preconception and prenatal …