Design, synthesis, biological evaluation, and structure–activity relationships of substituted phenyl 4-(2-oxoimidazolidin-1-yl) benzenesulfonates as new tubulin …
Sixty-one phenyl 4-(2-oxoimidazolidin-1-yl) benzenesulfonates (PIB-SOs) and 13 of their
tetrahydro-2-oxopyrimidin-1 (2 H)-yl analogues (PPB-SOs) were prepared and biologically …
tetrahydro-2-oxopyrimidin-1 (2 H)-yl analogues (PPB-SOs) were prepared and biologically …
New N-Arachidonoylserotonin Analogues with Potential “Dual” Mechanism of Action against Pain
G Ortar, MG Cascio, L De Petrocellis… - Journal of medicinal …, 2007 - ACS Publications
N-Arachidonoylserotonin (AA-5-HT, 1a) is an inhibitor of fatty acid amide hydrolase (FAAH)
that acts also as an antagonist of transient receptor potential vanilloid-type 1 (TRPV1) …
that acts also as an antagonist of transient receptor potential vanilloid-type 1 (TRPV1) …
Synthesis of fluorinated analogues of sphingosine-1-phosphate antagonists as potential radiotracers for molecular imaging using positron emission tomography
VP Prasad, S Wagner, P Keul, S Hermann… - Bioorganic & Medicinal …, 2014 - Elsevier
Abstract Sphingosine-1-phosphate (S1P) receptors play major roles in cardiovascular,
immunological and neurological diseases. The recent approval of the sphingolipid drug …
immunological and neurological diseases. The recent approval of the sphingolipid drug …
Uji aktivitas in-silico senyawa baru 1-benzil-3-benzoilurea induk dan tersubstitusi sebagai agen antiproliferatif
F Suhud - Jurnal Farmasi Indonesia, 2015 - repository.ubaya.ac.id
Studi ini dilakukan terkait dengan rancangan dan penambatan molekul senyawa baru 1-
benzil-3-benzoilurea induk dan tersubstitusi sebagai antiproliferatif, dengan tujuan untuk …
benzil-3-benzoilurea induk dan tersubstitusi sebagai antiproliferatif, dengan tujuan untuk …
Styryl-N-phenyl-N′-(2-chloroethyl) ureas and styrylphenylimidazolidin-2-ones as new potent microtubule-disrupting agents using combretastatin A-4 as model
M Gagné-Boulet, S Fortin, J Lacroix… - European Journal of …, 2015 - Elsevier
Abstract Combretastatin A-4 (CA-4) is a well-studied and attractive molecular template to
develop new antimitotics. Several thousand of modifications were performed on the ring B …
develop new antimitotics. Several thousand of modifications were performed on the ring B …
Synthesis, Biological Evaluation, and Structure–Activity Relationships of Novel Substituted N-Phenyl Ureidobenzenesulfonate Derivatives Blocking Cell Cycle …
V Turcotte, S Fortin, F Vevey, Y Coulombe… - Journal of medicinal …, 2012 - ACS Publications
Twenty-eight new substituted N-phenyl ureidobenzenesulfonate (PUB-SO) and 18 N-
phenylureidobenzenesulfonamide (PUB-SA) derivatives were prepared. Several PUB-SOs …
phenylureidobenzenesulfonamide (PUB-SA) derivatives were prepared. Several PUB-SOs …
Synthesis, antiproliferative activity evaluation and structure–activity relationships of novel aromatic urea and amide analogues of N-phenyl-N′-(2-chloroethyl) ureas
Seven subsets of aromatic urea and amide analogues of N-phenyl-N′-(2-chloroethyl)
ureas (CEU) have been synthesized by nucleophilic addition of 3-chloropropylisocyanate, 2 …
ureas (CEU) have been synthesized by nucleophilic addition of 3-chloropropylisocyanate, 2 …
N-Phenyl-N′-(2-chloroethyl) urea analogues of combretastatin A-4: Is the N-phenyl-N′-(2-chloroethyl) urea pharmacophore mimicking the trimethoxy phenyl moiety …
A series of novel N-phenyl-N′-(2-chloroethyl) urea derivatives potentially mimicking the
structure of combretastatin A-4 were synthesized and tested for their cell growth inhibition …
structure of combretastatin A-4 were synthesized and tested for their cell growth inhibition …
N-Phenyl-N′-(2-chloroethyl) ureas (CEUs) as potential antineoplastic agents. Part 3: Role of carbonyl groups in the covalent binding to the colchicine-binding site
In the course of the development of N-phenyl-N′-(2-chloroethyl) ureas (CEUs) as potential
antineoplastic agents, we investigated the effect of carbonylated substituting chains of the …
antineoplastic agents, we investigated the effect of carbonylated substituting chains of the …
Facile synthesis of dithiatetraaza-macrocycles of potential anti-inflammatory activity
AS Girgis - European journal of medicinal chemistry, 2008 - Elsevier
A facile synthetic approach towards dithiatetraaza-macrocycles 4a and b was achieved
through reaction of 2, 2′-[alkanediylbis (thio)] bisbenzenamines 1a and b with 1, 4 …
through reaction of 2, 2′-[alkanediylbis (thio)] bisbenzenamines 1a and b with 1, 4 …