Tissue development, wound healing, pathogenesis, regeneration, and homeostasis rely
upon coordinated and dynamic spatial and temporal remodeling of extracellular matrix …

During the development of atherosclerosis and other vascular diseases, vascular smooth
muscle cells (SMCs) located in the intima and media of blood vessels shift from a contractile …

Mechanical compliance has been demonstrated to be a key determinant of cell behavior,
directing processes such as spreading, migration, and differentiation. Durotaxis, directional …

Hydrogels consisting of controlled fractions of alginate, gelatin, and Matrigel enable the
development of patient-derived bioprinted tissue models that support cancer spheroid …

Tissue engineered vascular grafts (TEVGs) have the ability to be tuned to match a target
vessel's compliance, diameter, wall thickness, and thereby prevent compliance mismatch. In …

As a first step towards the production of functional cell sheets applicable for the regeneration
of gut muscle layer, microstructured bacterial cellulose (mBC) was assessed for its ability to …

Cancer progression and metastasis are processes heavily controlled by the integrin receptor
family. Integrins are cell adhesion molecules that constitute the central components of …

The stiffness of arterial wall in response to cardiovascular diseases has been associated
with the changes in extracellular matrix (ECM) proteins, ie., collagen and elastin. Vascular …

Vascular smooth muscle cells (VSMCs) are the predominant cell type in the arterial wall and
normally adopt a quiescent, contractile phenotype to regulate vascular tone. In the arterial …

Human pluripotent stem cell-derived vascular smooth muscle cells (hPSC-VSMCs) are of
great value for disease modeling, drug screening, cell therapies, and tissue engineering …