• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Hypertension affects the vast majority of patients with CKD and increases the risk of
cardiovascular disease, ESKD, and death. Over the past decade, a number of hypertension …

Hypertension management forms a cornerstone of cardiovascular prevention. Strong
evidence is available supporting the benefits of blood pressure (BP) lowering in older adults …

Purpose Both heart failure and its treatment with diuretics or SGLT2 inhibitors increase fall
risk in older adults. Therefore, decisions to continue or deprescribe diuretics or SGLT2 …

Background This is the first update of this review first published in 2009. When treating
elevated blood pressure, doctors usually try to achieve a blood pressure target. That target is …

Summary Background The 2018 European Society of Cardiology/European Society of
Hypertension (ESC/ESH) guidelines for management of hypertension in adults aged≥ 65 …

Orthostatic hypotension (OH) is a cardinal sign of cardiovascular (CV) autonomic
dysfunction as a result of autonomic nervous system failure to control the postural …

Aims Cerebral hypoperfusion is implicated in the pathogenesis of associations between
orthostatic hypotension and adverse outcome such as falls, cognitive impairment …

Hypertension is commonly diagnosed in older patients, with increasing cardiovascular (CV)
risk as systolic blood pressure (BP) increases. Maximising CV risk reduction must be …

Hypertension management is challenging in frail older adults. The balance between
treatment risks and benefits may be difficult to achieve due to an increased vulnerability to …