(1) Background: Iron deficiency (ID) is an important adverse prognostic marker in patients
with heart failure (HF); however, it is unclear whether intravenous iron replacement reduces …

Background and Objectives: The heart is the organ with the highest metabolic demand in the
body, and it relies on high ATP turnover and efficient energy substrate utilisation in order to …

Cardiovascular diseases are the leading cause of death worldwide. Several strategies–
small molecules, gene therapy, surgeries, cardiac rehabilitation–have been developed to …

Summary Perlecan (HSPG2), a heparan sulfate proteoglycan similar to agrin, is key for
extracellular matrix (ECM) maturation and stabilization. Although crucial for cardiac …

Growing evidence indicates that metabolites and energy metabolism play an active rather
than consequential role in regulating cellular fate. Cardiac development requires dramatic …

Mushrooms fortified with iron (Fe) can offer a promising alternative to counter the worldwide
deficiency problem. However, the factors that may influence the efficiency of fortification …

Heparan sulfate proteoglycans (HSPGs) contribute to structural integrity and signalling
regulation during cardiac development, healing, and wound repair, one such HSPG being …