Neuronal hyperexcitability in Alzheimer's disease: what are the drivers behind this aberrant phenotype?
Alzheimer's disease (AD) is a progressive neurodegenerative disorder leading to loss of
cognitive abilities and ultimately, death. With no cure available, limited treatments mostly …
cognitive abilities and ultimately, death. With no cure available, limited treatments mostly …
Network abnormalities and interneuron dysfunction in Alzheimer disease
The function of neural circuits and networks can be controlled, in part, by modulating the
synchrony of their components' activities. Network hypersynchrony and altered oscillatory …
synchrony of their components' activities. Network hypersynchrony and altered oscillatory …
A review on mechanical considerations for chronically-implanted neural probes
A Lecomte, E Descamps… - Journal of neural …, 2018 - iopscience.iop.org
This review intends to present a comprehensive analysis of the mechanical considerations
for chronically-implanted neural probes. Failure of neural electrical recordings or stimulation …
for chronically-implanted neural probes. Failure of neural electrical recordings or stimulation …
The future of neuroscience: flexible and wireless implantable neural electronics
Neurological diseases are a prevalent cause of global mortality and are of growing concern
when considering an ageing global population. Traditional treatments are accompanied by …
when considering an ageing global population. Traditional treatments are accompanied by …
Neuronal network excitability in Alzheimer's disease: the puzzle of similar versus divergent roles of amyloid β and tau
Alzheimer's disease (AD) is the most frequent neurodegenerative disorder that commonly
causes dementia in the elderly. Recent evidence indicates that network abnormalities …
causes dementia in the elderly. Recent evidence indicates that network abnormalities …
Soluble Aβ oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance
Epileptic activity may be more prevalent in early stage Alzheimer's disease (AD) than
previously believed. Several studies report spontaneous seizures and interictal discharges …
previously believed. Several studies report spontaneous seizures and interictal discharges …
Excitatory-inhibitory imbalance in Alzheimer's disease and therapeutic significance
EV Varela, G Etter, S Williams - Neurobiology of disease, 2019 - Elsevier
The interplay between excitatory and inhibitory circuits underlies the brain's processes and
their dysregulation has been linked to cognitive decline, psychiatric disorders and epilepsy …
their dysregulation has been linked to cognitive decline, psychiatric disorders and epilepsy …
Interictal spikes during sleep are an early defect in the Tg2576 mouse model of β-amyloid neuropathology
It has been suggested that neuronal hyperexcitability contributes to Alzheimer's disease
(AD), so we asked how hyperexcitability develops in a common mouse model of β-amyloid …
(AD), so we asked how hyperexcitability develops in a common mouse model of β-amyloid …
Early-onset network hyperexcitability in presymptomatic Alzheimer's disease transgenic mice is suppressed by passive immunization with anti-human APP/Aβ …
Cortical and hippocampal network hyperexcitability appears to be an early event in
Alzheimer's disease (AD) pathogenesis, and may contribute to memory impairment. It …
Alzheimer's disease (AD) pathogenesis, and may contribute to memory impairment. It …
Astrocyte and glutamate involvement in the pathogenesis of epilepsy in Alzheimer's disease
Alzheimer's disease (AD) can increase the risk of epilepsy by up to 10‐fold compared to
healthy age‐matched controls. However, the pathological mechanisms that underlie this …
healthy age‐matched controls. However, the pathological mechanisms that underlie this …