Accumulation of phosphorylated intermediates during cellular metabolism can have wide-
ranging toxic effects on many organisms, including humans and the pathogens that infect …

In most organisms, productive utilization of galactose requires the highly conserved Leloir
pathway of galactose metabolism. Yet, if this metabolic pathway is perturbed due to …

Myoinositol synthesis and catabolism are crucial in many multiceullar eukaryotes for the
production of phosphatidylinositol signaling molecules, glycerophosphoinositide membrane …

Classic galactosemia is a genetic disorder that results from profound loss of galactose-1P-
uridylyltransferase (GALT). Affected infants experience a rapid escalation of potentially lethal …

Classic Galactosemia is an autosomal recessive disorder caused by the deficiency of
galactose-1-phosphate uridylyltransferase (GALT), one of the key enzymes in the Leloir …

The metabolism of galactose via enzymes of the Leloir pathway: galactokinase, galactose-1-
P uridylyltransferase, and UDP galactose-4′-epimerase, is a process that has been …

Aspergillus nidulans UDP-glucose-4-epimerase UgeA interconverts UDP-glucose and UDP-
galactose and participates in galactose metabolism. The sugar moiety of UDP-galactose is …

Classic galactosemia (CG) results from profound deficiency of galactose‐1‐P
uridylyltransferase (GALT). Despite early detection by newborn screening and lifelong …

The uptake and catabolism of galactose by the yeast Saccharomyces cerevisiae is much
lower than for glucose and fructose, and in applications of this yeast for utilization of complex …

UDPgalactose 4‐epimerase (epimerase) catalyzes the reversible conversion between
UDPgalactose and UDPglucose and is an important enzyme of the galactose metabolic …