Breath biomarkers in diagnostic applications

YL Pham, J Beauchamp - Molecules, 2021 - mdpi.com
The detection of chemical compounds in exhaled human breath presents an opportunity to
determine physiological state, diagnose disease or assess environmental exposure. Recent …

The need for multicomponent gas standards for breath biomarker analysis

KM Jeerage, JL Berry, JA Murray… - Journal of Breath …, 2022 - iopscience.iop.org
Exhaled breath is a non-invasive, information-rich matrix with the potential to diagnose or
monitor disease, including infectious disease. Despite significant effort dedicated to …

Breath biopsy reveals systemic immunothrombosis and its resolution through bioorthogonal dendritic nanoprobes

Y Zhang, E Ranaei Pirmardan, A Barakat… - Advanced …, 2023 - Wiley Online Library
Immunothrombosis, an inflammation‐dependent activation of the coagulation cascade,
leads to microthrombi formations in small vessels. It is a dreaded complication of COVID‐19 …

Emissions and uptake of volatiles by sampling components in breath analysis

YL Pham, O Holz, J Beauchamp - Journal of Breath Research, 2023 - iopscience.iop.org
The first and most crucial step in breath research is adequate sampling, which plays a
pivotal role in quality assurance of breath datasets. In particular, the emissions or uptake of …

Increasing the robustness of SIFT-MS volatilome fingerprinting by introducing notional analyte concentrations

A Benchennouf, M Corion, A Dizon… - Journal of the …, 2023 - ACS Publications
Selected ion flow tube-mass spectrometry (SIFT-MS) is an analytical technique for volatile
detection and quantification. SIFT-MS can be applied in a “white box” approach, measuring …

Peppermint protocol: first results for gas chromatography-ion mobility spectrometry

DM Ruszkiewicz, R Myers, B Henderson… - Journal of Breath …, 2022 - iopscience.iop.org
Abstract The Peppermint Initiative seeks to inform the standardisation of breath analysis
methods. Five Peppermint Experiments with gas chromatography-ion mobility spectrometry …

Cross-validation of the peppermint benchmarking experiment across three analytical platforms

YL Pham, R Yu, J Beauchamp - Journal of Breath Research, 2023 - iopscience.iop.org
Abstract The Peppermint Experiment is a breath analysis benchmarking initiative that seeks
to address the lack of inter-comparability of outcomes across independent breath biomarker …

A gas-phase standard delivery system for direct breath analysis

B Streckenbach, J Sakas, N Perkins… - Journal of breath …, 2022 - iopscience.iop.org
Applications for direct breath analysis by mass spectrometry (MS) are rapidly expanding.
One of the more recent mass spectrometry-based approaches is secondary electrospray …

Origin and Emission of Volatile Biomarkers in Breath: End-tidal Perspective

V Ruzsanyi, F Lochmann, S Jürschik, P Mochalski… - 2022 - books.rsc.org
The volatile organic compound (VOC) composition of exhaled breath is complex and
determined by many internal and external factors, such as metabolic, inflammatory and …

Benchmarking breath analysis using peppermint approach with gas chromatography ion mobility spectrometer coupled to micro thermal desorber.

DM Ruszkiewicz, KJ Kiland, Y Mok… - Journal of Breath …, 2024 - iopscience.iop.org
Abstract Background The Peppermint Initiative, established within the International
Association of Breath Research, introduced the peppermint protocol, a breath analysis …