Negative symptoms of schizophrenia are associated with poor functional outcome and place
a substantial burden on people with this disorder, their families, and health-care systems …

A recent increase in the literature regarding the evidence base for clozapine has made it
increasingly difficult for clinicians to judge “best evidence” for clozapine use. As such, we …

Objective: The dose-response relationships of antipsychotic drugs for schizophrenia are not
well defined, but such information would be important for decision making by clinicians. The …

PRESCRIPTION DRUGS ARE THE THIRD LEADING CAUSE OF DEATH AFTER HEART
DISEASE AND CANCER. In his latest ground-breaking book, Peter C Gotzsche exposes the …

Background The question of which antipsychotic drug should be preferred for the treatment
of schizophrenia is controversial, and conventional pairwise meta-analyses cannot provide …

Originally published in February 2004. This guideline is more than 5 years old and has not
yet been updated to ensure that it reflects current knowledge and practice. In accordance …

Background Because of the debate about whether second-generation antipsychotic drugs
are better than first-generation antipsychotic drugs, we did a meta-analysis of randomised …

Background The relative effectiveness of second-generation (atypical) antipsychotic drugs
as compared with that of older agents has been incompletely addressed, though newer …

READ ALL ABOUT IT! David Spiegelhalter has recently joined the ranks of Isaac Newton,
Charles Darwin and Stephen Hawking by becoming a fellow of the Royal Society …

Background: Several clinical and research applications require an estimation of therapeutic
dose equivalence across antipsychotic medications. Since the advent of the newer atypical …