Calcium-release channels: structure and function of IP3 receptors and ryanodine receptors
KA Woll, F Van Petegem - Physiological Reviews, 2022 - journals.physiology.org
Ca2+-release channels are giant membrane proteins that control the release of Ca2+ from
the endoplasmic and sarcoplasmic reticulum. The two members, ryanodine receptors …
the endoplasmic and sarcoplasmic reticulum. The two members, ryanodine receptors …
The inositol trisphosphate/calcium signaling pathway in health and disease
MJ Berridge - Physiological reviews, 2016 - journals.physiology.org
Many cellular functions are regulated by calcium (Ca2+) signals that are generated by
different signaling pathways. One of these is the inositol 1, 4, 5-trisphosphate/calcium …
different signaling pathways. One of these is the inositol 1, 4, 5-trisphosphate/calcium …
Capture at the ER-mitochondrial contacts licenses IP3 receptors to stimulate local Ca2+ transfer and oxidative metabolism
Endoplasmic reticulum-mitochondria contacts (ERMCs) are restructured in response to
changes in cell state. While this restructuring has been implicated as a cause or …
changes in cell state. While this restructuring has been implicated as a cause or …
The regulation of autophagy by calcium signals: Do we have a consensus?
Abstract Macroautophagy (hereafter called 'autophagy') is a cellular process for degrading
and recycling cellular constituents, and for maintenance of cell function. Autophagy initiates …
and recycling cellular constituents, and for maintenance of cell function. Autophagy initiates …
Structure and function of IP3 receptors
Inositol 1, 4, 5-trisphosphate receptors (IP3Rs), by releasing Ca2+ from the endoplasmic
reticulum (ER) of animal cells, allow Ca2+ to be redistributed from the ER to the cytosol or …
reticulum (ER) of animal cells, allow Ca2+ to be redistributed from the ER to the cytosol or …
IP3 receptors preferentially associate with ER-lysosome contact sites and selectively deliver Ca2+ to lysosomes
P Atakpa, NB Thillaiappan, S Mataragka, DL Prole… - Cell reports, 2018 - cell.com
Summary Inositol 1, 4, 5-trisphosphate (IP 3) receptors (IP 3 Rs) allow extracellular stimuli to
redistribute Ca 2+ from the ER to cytosol or other organelles. We show, using small …
redistribute Ca 2+ from the ER to cytosol or other organelles. We show, using small …
Omnitemporal choreographies of all five STIM/Orai and IP3Rs underlie the complexity of mammalian Ca2+ signaling
SM Emrich, RE Yoast, P Xin, V Arige, LE Wagner… - Cell reports, 2021 - cell.com
Summary Stromal-interaction molecules (STIM1/2) sense endoplasmic reticulum (ER) Ca 2+
depletion and activate Orai channels. However, the choreography of interactions between …
depletion and activate Orai channels. However, the choreography of interactions between …
Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis
N Rosa, H Ivanova, LE Wagner 2nd, J Kale… - Cell Death & …, 2022 - nature.com
Abstract Anti-apoptotic Bcl-2-family members not only act at mitochondria but also at the
endoplasmic reticulum, where they impact Ca2+ dynamics by controlling IP3 receptor (IP3R) …
endoplasmic reticulum, where they impact Ca2+ dynamics by controlling IP3 receptor (IP3R) …
Conformational motions and ligand-binding underlying gating and regulation in IP3R channel
Abstract Inositol-1, 4, 5-trisphosphate receptors (IP3Rs) are activated by IP3 and Ca2+ and
their gating is regulated by various intracellular messengers that finely tune the channel …
their gating is regulated by various intracellular messengers that finely tune the channel …
Ca2+ signals initiate at immobile IP3 receptors adjacent to ER-plasma membrane junctions
NB Thillaiappan, AP Chavda, SC Tovey… - Nature …, 2017 - nature.com
Abstract IP3 receptors (IP3Rs) release Ca2+ from the ER when they bind IP3 and Ca2+. The
spatial organization of IP3Rs determines both the propagation of Ca2+ signals between …
spatial organization of IP3Rs determines both the propagation of Ca2+ signals between …