In contrast to other cancer types, melanoma incidence has been increasing over the last 50
years, and while it still represents less than 5% of all cutaneous malignancies, melanoma …

Simple Summary Melanocytic tumors are among the most common cutaneous neoplasms in
horses. Contrary to popular opinion, the slow rate of growth typical of these tumors does not …

Objective—To identify epidemiological trends in cutaneous neoplasms affecting equids in
central North America and compare them with previously reported trends. Design …

Horses are valued for the beauty and variety of colouration and coat patterning. To date,
eleven different genes have been characterized that contribute to the variation observed in …

The Greying with age phenotype in horses involves loss of hair pigmentation whereas skin
pigmentation is not reduced, and a predisposition to melanoma. The causal mutation was …

Melanocytes are dendritic cells derived from neuroectodermal melanoblasts that have
migrated during embryogenesis to the epidermis, dermis, and other sites (eg, eye, inner ear …

The dominant phenotype of greying with age in horses, caused by a 4.6-kb duplication in
intron 6 of STX17, is associated with a high incidence of melanoma and vitiligo-like skin …

Equine melanoma shows striking features particularly with regard to clinical development in
grey horses: in contrast to malignant melanoma in humans and in solid coloured horses that …

Simple Summary Programmed cell death-ligand 1 (PD-L1) is expressed by several tumors,
promoting tumoral immunosuppression by binding to programmed cell death protein (PD-1) …

Debate surrounding the nature of equine melanoma has resulted in an underestimation of
its life‐threatening potential. Contrary to popular dogma, the variable, often slow, rate of …