Mucosal administration, and specifically nasal route, constitutes an alternative and
promising strategy for drug and vaccine delivery. Mucosal routes have several advantages …

Bordetella pertussis causes whooping cough, a severe respiratory tract infection in infants
and children, and also infects adults. Studies in murine models have shown that innate …

Practical Handbook of Microbiology, 4th edition provides basic, clear and concise
knowledge and practical information about working with microorganisms. Useful to anyone …

Background Bordetella pertussis epidemics persist as transmission remains unabated
despite high acellular pertussis vaccination rates. BPZE1, a live attenuated intranasal …

Background Resurgence of pertussis in the post-vaccination era has been reported in
Western countries. A shift of cases from school-age children to adolescents, adults and …

Pertussis toxin, produced and secreted by the whooping cough agent Bordetella pertussis,
is one of the most complex soluble bacterial proteins. It is actively secreted through the B …

Background Acellular pertussis vaccines do not control pertussis. A new approach to offer
protection to infants is necessary. BPZE1, a genetically modified Bordetella pertussis strain …

Viruses, bacteria, fungi, and several other pathogenic microorganisms usually infect the host
via the surface cells of respiratory mucosa. Nasal vaccination could provide a strong …

Background Measles vaccines (MV) have sex-differential effects on mortality not explained
by protection against measles infection. Objective The authors examined whether whole-cell …

Pertussis, caused by respiratory tract infection with the bacterial pathogen Bordetella
pertussis, has long been considered to be a toxin-mediated disease. Bacteria adhere and …