Amino acid transporter LAT1 (SLC7A5) as a molecular target for cancer diagnosis and therapeutics
Y Kanai - Pharmacology & therapeutics, 2022 - Elsevier
Cancer cells require a massive supply of nutrients, including sugars and amino acids—the
upregulation of transporters for each nutrient contributes to meet the demand. Distinct from …
upregulation of transporters for each nutrient contributes to meet the demand. Distinct from …
SLC6 neurotransmitter transporters: structure, function, and regulation
AS Kristensen, J Andersen, TN Jørgensen… - Pharmacological …, 2011 - Elsevier
The neurotransmitter transporters (NTTs) belonging to the solute carrier 6 (SLC6) gene
family (also referred to as the neurotransmitter-sodium-symporter family or Na+/Cl …
family (also referred to as the neurotransmitter-sodium-symporter family or Na+/Cl …
Illumination of serotonin transporter mechanism and role of the allosteric site
The serotonin transporter (SERT) terminates serotonin signaling by using sodium and
chloride gradients to drive reuptake of serotonin into presynaptic neurons and is the target of …
chloride gradients to drive reuptake of serotonin into presynaptic neurons and is the target of …
X-ray structures and mechanism of the human serotonin transporter
The serotonin transporter (SERT) terminates serotonergic signalling through the sodium-and
chloride-dependent reuptake of neurotransmitter into presynaptic neurons. SERT is a target …
chloride-dependent reuptake of neurotransmitter into presynaptic neurons. SERT is a target …
What contributes to serotonin–norepinephrine reuptake inhibitors' dual-targeting mechanism? The key role of transmembrane domain 6 in human serotonin and …
Dual inhibition of serotonin and norepinephrine transporters (hSERT and hNET) gives
greatly improved efficacy and tolerability for treating major depressive disorder (MDD) …
greatly improved efficacy and tolerability for treating major depressive disorder (MDD) …
Identification of drug transporter genomic variants and inhibitors that protect against doxorubicin-induced cardiotoxicity
Background: Multiple pharmacogenomic studies have identified the synonymous genomic
variant rs7853758 (G> A, L461L) and the intronic variant rs885004 in SLC28A3 (solute …
variant rs7853758 (G> A, L461L) and the intronic variant rs885004 in SLC28A3 (solute …
The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter
P Plenge, D Yang, K Salomon, L Laursen… - Nature …, 2021 - nature.com
Depression is a common mental disorder. The standard medical treatment is the selective
serotonin reuptake inhibitors (SSRIs). All characterized SSRIs are competitive inhibitors of …
serotonin reuptake inhibitors (SSRIs). All characterized SSRIs are competitive inhibitors of …
Targeting SLC transporters: small molecules as modulators and therapeutic opportunities
A Schlessinger, N Zatorski, K Hutchinson… - Trends in Biochemical …, 2023 - cell.com
Solute carrier (SLCs) transporters mediate the transport of a broad range of solutes across
biological membranes. Dysregulation of SLCs has been associated with various …
biological membranes. Dysregulation of SLCs has been associated with various …
The solute carrier 6 family of transporters
The solute carrier 6 (SLC6) family of the human genome comprises transporters for
neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family …
neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family …
Structural basis for recognition of diverse antidepressants by the human serotonin transporter
JA Coleman, E Gouaux - Nature structural & molecular biology, 2018 - nature.com
Selective serotonin reuptake inhibitors are clinically prescribed antidepressants that act by
increasing the local concentrations of neurotransmitters at synapses and in extracellular …
increasing the local concentrations of neurotransmitters at synapses and in extracellular …