Lipopolysaccharide (LPS) from Gram-negative bacteria is one of the most potent innate
immune-activating stimuli known. Here we review the current understanding of LPS effects …

▪ Abstract The Class 2 α-helical cytokines consist of interleukin-10 (IL-10), IL-19, IL-20, IL-22,
IL-24 (Mda-7), and IL-26, interferons (IFN-α,-β,-ε,-κ,-ω,-δ,-τ, and-γ) and interferon-like …

Advancing our understanding of mechanisms of immune regulation in allergy, asthma,
autoimmune diseases, tumor development, organ transplantation, and chronic infections …

The Growth Arrest and DNA Damage-inducible 45 (GADD45) proteins have been implicated
in regulation of many cellular functions including DNA repair, cell cycle control, senescence …

Class II cytokine receptors were originally defined on the basis of sequence homologies in
the extracellular domains of receptors for interferons (IFNs) and interleukin-10 (IL-10), and …

MicroRNAs (miRNAs) regulate gene expression by repressing translation or directing
sequence-specific degradation of complementary mRNA. Here, we report that expression of …

Subtraction hybridization identified melanoma differentiation-associated gene-7 (mda-7) as
a gene induced during terminal differentiation in human melanoma cells. On the basis of …

The melanoma differentiation-associated gene 7 (mda-7) has been studied primarily in the
context of its tumor suppressor activity. Although mda-7 has been designated as IL-24 based …

Five novel cytokines (IL-19, IL-20, IL-22 (IL-TIF), IL-24 (human MDA-7, mouse FISP, rat
C49A/Mob-5), and IL-26 (AK155)) demonstrating limited primary sequence identity and …

Glutamate transport is central to neurotransmitter functions in the brain. Impaired glutamate
transport induces neurotoxicity associated with numerous pathological processes, including …