Fungal membrane organization: the eisosome concept

LM Douglas, JB Konopka - Annual review of microbiology, 2014 - annualreviews.org
The fungal plasma membrane is organized into specialized domains that vary in size,
stability, and composition. Membrane compartment of Can1 (MCC)/eisosome domains that …

BRCT Domains: Structure, Functions, and Implications in Disease—New Therapeutic Targets for Innovative Drug Discovery against Infections

J Peña-Guerrero, C Fernández-Rubio, AT García-Sosa… - Pharmaceutics, 2023 - mdpi.com
The search for new therapeutic targets and their implications in drug development remains
an emerging scientific topic. BRCT-bearing proteins are found in Archaea, Bacteria …

Properties and identification of human protein drug targets

TM Bakheet, AJ Doig - Bioinformatics, 2009 - academic.oup.com
Motivation: We analysed 148 human drug target proteins and 3573 non-drug targets to
identify differences in their properties and to predict new potential drug targets. Results …

Association of hypertension drug target genes with blood pressure and hypertension in 86 588 individuals

AD Johnson, C Newton-Cheh, DI Chasman… - …, 2011 - Am Heart Assoc
We previously conducted genome-wide association meta-analysis of systolic blood
pressure, diastolic blood pressure, and hypertension in 29 136 people from 6 cohort studies …

Mapping adverse drug reactions in chemical space

J Scheiber, JL Jenkins, SCK Sukuru… - Journal of medicinal …, 2009 - ACS Publications
We present a novel method to better investigate adverse drug reactions in chemical space.
By integrating data sources about adverse drug reactions of drugs with an established …

Global DNA methylation changes in Nile tilapia gonads during high temperature-induced masculinization

LX Sun, YY Wang, Y Zhao, H Wang, N Li, XS Ji - PLoS One, 2016 - journals.plos.org
In some fish species, high or low temperature can switch the sex determination mechanisms
and induce fish sex reversal when the gonads are undifferentiated. During this high or low …

Effect of exercise on microglial activation and transcriptome of hippocampus in fluorosis mice

J Wang, B Yue, X Zhang, X Guo, Z Sun, R Niu - Science of the Total …, 2021 - Elsevier
Fluorosis is a widespread endemic disease. Reports have shown that high fluoride causes
the dysfunction of central nervous system (CNS) in animals. The neurotoxicity of fluoride …

Exploring the mechanism of Suanzaoren decoction in treatment of insomnia based on network pharmacology and molecular docking

S Wang, Y Zhao, X Hu - Frontiers in pharmacology, 2023 - frontiersin.org
Objective: To explore the functional mechanisms of Suanzaoren decoction (SZRD) for
treating insomnia using network pharmacology and molecular docking. Methods: The active …

Transcriptome analysis of ovary tissues from low-and high-yielding Changshun green-shell laying hens

R Mu, Y Yu, T Gegen, D Wen, F Wang, Z Chen, W Xu - Bmc Genomics, 2021 - Springer
Background Changshun green-shell laying hens are unique to Guizhou Province, China,
and have high egg quality. Improving egg production performance has become an important …

[HTML][HTML] Analysis of differentially expressed genes, clinical value and biological pathways in prostate cancer

Z He, F Tang, Z Lu, Y Huang, H Lei, Z Li… - American journal of …, 2018 - ncbi.nlm.nih.gov
Analysis of differentially expressed genes, clinical value and biological pathways in prostate
cancer - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage …