Tryptophan (Trp) metabolism primarily involves the kynurenine, 5-hydroxytryptamine, and
indole pathways. A variety of bioactive compounds produced via Trp metabolism can …

Tryptophan (TRP), an essential amino acid in mammals, is involved in several physiological
processes including neuronal function, immunity, and gut homeostasis. In humans, TRP is …

The importance of tryptophan as a precursor for neuroactive compounds has long been
acknowledged. The metabolism of tryptophan along the kynurenine pathway and its …

Evidence is mounting that the gut-brain axis plays an important role in mental diseases
fueling mechanistic investigations to provide a basis for future targeted interventions …

Accumulating evidence suggests that gut microbiota plays a role in the pathogenesis of
schizophrenia via the microbiota–gut–brain axis. This study sought to investigate whether …

The kynurenine pathway (KP) of tryptophan (TRP) catabolism links immune system
activation with neurotransmitter signaling. The KP metabolite kynurenic acid (KYNA) is …

Currently, due to the large number of reports regarding the harmfulness of food additives,
more and more consumers follow the so-called “clean label” trend, ie, prefer and choose the …

Neurological and psychiatric disorders are a category of chronic diseases that are
widespread and pose serious mental and physical health problems for patients. The …

The tryptophan catabolite (TRYCAT) pathway is implicated in the pathophysiology of
schizophrenia (SCZ) since the rate-limiting enzyme indoleamine-dioxygenase (IDO) may be …

Schizophrenia is a chronic, heterogeneous neurodevelopmental disorder that has complex
symptoms and uncertain etiology. Mounting evidence indicates the involvement of genetics …