[HTML][HTML] Mutations at protein-protein interfaces: Small changes over big surfaces have large impacts on human health
Many essential biological processes including cell regulation and signalling are mediated
through the assembly of protein complexes. Changes to protein-protein interaction (PPI) …
through the assembly of protein complexes. Changes to protein-protein interaction (PPI) …
Biophysical and computational fragment-based approaches to targeting protein–protein interactions: applications in structure-guided drug discovery
A Winter, AP Higueruelo, M Marsh… - Quarterly reviews of …, 2012 - cambridge.org
Drug discovery has classically targeted the active sites of enzymes or ligand-binding sites of
receptors and ion channels. In an attempt to improve selectivity of drug candidates …
receptors and ion channels. In an attempt to improve selectivity of drug candidates …
Towards the prediction of protein interaction partners using physical docking
Deciphering the whole network of protein interactions for a given proteome ('interactome') is
the goal of many experimental and computational efforts in Systems Biology. Separately the …
the goal of many experimental and computational efforts in Systems Biology. Separately the …
Genes and 'in-vironment': how will our concepts on the pathophysiology of inflammatory bowel disease develop in the future?
C Fiocchi - Digestive diseases, 2013 - karger.com
It is becoming increasingly evident that the old paradigm of disease pathogenesis where a
given genotype would determine a phenotype and this would lead to a particular disease is …
given genotype would determine a phenotype and this would lead to a particular disease is …
Pharmacoproteomics: a chess game on a protein field
A D'Alessandro, L Zolla - Drug discovery today, 2010 - Elsevier
The application of proteomics in the field of drug discovery development and the
assessment of drug administration is known as pharmacoproteomics. As a branch of …
assessment of drug administration is known as pharmacoproteomics. As a branch of …
Spatial and temporal organization of multi-protein assemblies: achieving sensitive control in information-rich cell-regulatory systems
The regulation of cellular processes in living organisms requires signalling systems that
have a high signal-to-noise ratio. This is usually achieved by transient, multi-protein …
have a high signal-to-noise ratio. This is usually achieved by transient, multi-protein …
Meet me halfway: when genomics meets structural bioinformatics
The DNA sequencing technology developed by Frederick Sanger in the 1970s established
genomics as the basis of comparative genetics. The recent invention of next-generation …
genomics as the basis of comparative genetics. The recent invention of next-generation …
'-omics' technology and human reproduction: reproductomics
J Bellver, M Mundi, FJ Esteban… - Expert Review of …, 2012 - Taylor & Francis
The success of assisted reproduction technology is highly dependent on a precise selection
of gametes and embryos and determining the best endometrial window for embryo …
of gametes and embryos and determining the best endometrial window for embryo …
[PDF][PDF] Point of View The Future of Inflammatory Bowel Disease: Integrating Knowledge to Advance Understanding and Reach a Cure
C Fiocchi - International Journal of Inflammatory Bowel Disease - xdocz.com.br
Most experts agree that the main components of inflammatory bowel disease (IBD) have
been identified, and they include the environment, genetic make-up, gut microbiota and the …
been identified, and they include the environment, genetic make-up, gut microbiota and the …
[PDF][PDF] Spatial and temporal organization of multi-protein
BL Sibanda, TL Blundell, VM Bolanos-Garcia, Q Wu… - researchgate.net
The regulation of cellular processes in living organisms requires signalling systems that
have a high signal-to-noise ratio. This is usually achieved by transient, multi-protein …
have a high signal-to-noise ratio. This is usually achieved by transient, multi-protein …