Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …

Chemokines are a family of cytokines that orchestrate the migration and positioning of
immune cells within tissues and are critical for the function of the immune system. CCR2 …

The interactions of chemokines with their G protein-coupled receptors promote the migration
of leukocytes during normal immune function and as a key aspect of the inflammatory …

Cirrhosis is defined as the histological development of regenerative nodules surrounded by
fibrous bands in response to chronic liver injury, which leads to portal hypertension and end …

More than 500 million people worldwide are persistently infected with the hepatitis B virus
(HBV) and/or hepatitis C virus (HCV) and are at risk of developing chronic liver disease …

Hepatic fibrosis develops as a response to chronic liver injury and almost exclusively occurs
in a proinflammatory environment. However, the role of inflammatory mediators in fibrogenic …

Activation of hepatic stellate cells in response to chronic inflammation represents a crucial
step in the development of liver fibrosis. However, the molecules involved in the interaction …

Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …

Background. Respiratory syncytial virus (RSV) is a common cause of severe lower
respiratory tract infection in infants. Only a proportion of children infected with RSV require …

The hepatic complications of chronic hepatitis C (CHC) usually occur only after progression
to cirrhosis has taken place. Progression to cirrhosis, however, is extremely variable and …