Porcine deltacoronaviruses: origin, evolution, cross-species transmission and zoonotic potential

F Kong, Q Wang, SP Kenney, K Jung, AN Vlasova… - Pathogens, 2022 - mdpi.com
Porcine deltacoronavirus (PDCoV) is an emerging enteropathogenic coronavirus of swine
that causes acute diarrhoea, vomiting, dehydration and mortality in seronegative neonatal …

Prevalence and phylogenetic analysis of porcine diarrhea associated viruses in southern China from 2012 to 2018

F Zhang, S Luo, J Gu, Z Li, K Li, W Yuan, Y Ye… - BMC Veterinary …, 2019 - Springer
Abstract Background In China, large-scale outbreaks of severe diarrhea caused by viruses
have occurred in pigs since late 2010. To investigate the prevalence and genetic evolution …

Porcine deltacoronavirus induces caspase-dependent apoptosis through activation of the cytochrome c-mediated intrinsic mitochondrial pathway

YJ Lee, C Lee - Virus research, 2018 - Elsevier
Porcine deltacoronavirus (PDCoV), a newly discovered enteric coronavirus, is a causative
agent of severe clinical diarrhea and intestinal pathological damage in piglets. As a first step …

Contribution of porcine aminopeptidase N to porcine deltacoronavirus infection

X Zhu, S Liu, X Wang, Z Luo, Y Shi… - Emerging Microbes & …, 2018 - Taylor & Francis
Porcine deltacoronavirus (PDCoV), a member of genus Deltacoronavirus, is an emerging
swine enteropathogenic coronavirus (CoV). Although outstanding efforts have led to the …

Expression of codon-optimized PDCoV-RBD protein in baculovirus expression system and immunogenicity evaluation in mice

N Wang, Z Wang, M Ma, X Jia, H Liu, M Qian… - International Journal of …, 2023 - Elsevier
Porcine deltacoronavirus (PDCoV) is a global epidemic enteropathogenic coronavirus that
mainly infects piglets, and causes huge losses to the pig industry. However, there are still no …

Trypsin promotes porcine deltacoronavirus mediating cell-to-cell fusion in a cell type-dependent manner

YL Yang, F Meng, P Qin, G Herrler… - Emerging microbes & …, 2020 - Taylor & Francis
Porcine deltacoronavirus (PDCoV) is a newly emerging threat to the global porcine industry.
PDCoV has been successfully isolated using various medium additives including trypsin …

Porcine deltacoronavirus nsp5 cleaves DCP1A to decrease its antiviral activity

X Zhu, J Chen, L Tian, Y Zhou, S Xu, S Long… - Journal of …, 2020 - Am Soc Microbiol
Porcine deltacoronavirus (PDCoV) is an emerging swine enteropathogenic coronavirus. The
nonstructural protein nsp5, also called 3C-like protease, is responsible for processing viral …

Co-infection of porcine deltacoronavirus and porcine epidemic diarrhea virus induces early TRAF6-mediated NF-κB and IRF7 signaling pathways through TLRs

K Saeng-Chuto, A Madapong, K Kaeoket… - Scientific Reports, 2022 - nature.com
Porcine deltacoronavirus (PDCoV) and porcine epidemic diarrhea virus (PEDV) infect the
small intestine and cause swine enteric coronavirus disease. The mucosal innate immune …

Porcine deltacoronavirus nsp5 antagonizes type I interferon signaling by cleaving IFIT3

H Huang, X Lei, C Zhao, Y Qin, Y Li, X Zhang… - Journal of …, 2024 - Am Soc Microbiol
Porcine deltacoronavirus (PDCoV) has caused enormous economic losses to the global pig
industry. However, the immune escape mechanism of PDCoV remains to be fully clarified …

Coinfection of porcine deltacoronavirus and porcine epidemic diarrhea virus increases disease severity, cell trophism and earlier upregulation of IFN-α and IL12

K Saeng-Chuto, A Madapong, K Kaeoket, PE Piñeyro… - Scientific reports, 2021 - nature.com
Porcine epidemic diarrhea virus (PEDV) and porcine deltacoronavirus (PDCoV) cause an
enteric disease characterized by diarrhea clinically indistinguishable. Both viruses are …