RESULTS: The main adverse effects of vancomycin are: hypotension, phlebitis,
nephrotoxicity, ototoxicity, hypersensitivity reactions, red man syndrome, neutropenia, chills …

Background Pharmacokinetics (PK) are severely altered in critically ill patients due to
changes in volume of distribution (Vd) and/or drug clearance (Cl). This affects the target …

Background: Our objectives were to (1) determine the pharmacokinetic indices of
vancomycin in pediatric patients; and (2) compare attainment of 2 target exposures: area …

Many critically ill patients display a supraphysiological renal function with enhanced renal
perfusion and glomerular hyperfiltration. This phenomenon described as augmented renal …

Children show important developmental and maturational changes, which may contribute
greatly to pharmacokinetic (PK) variability observed in pediatric patients. These PK …

Developmental and physiological changes in children contribute to variation in drug
disposition with age. Additionally, critically ill children suffer from various life-threatening …

Background In adults, the area under the concentration–time curve (AUC) divided by the
minimum inhibitory concentration (MIC) is associated with better clinical and bacteriological …

Because of the recent awareness that vancomycin doses should aim to meet a target area
under the concentration-time curve (AUC) instead of trough concentrations, more aggressive …

The review includes studies dated 2011–2021 presenting the newest information on
voriconazole (VCZ), mycophenolic acid (MPA), and vancomycin (VAN) therapeutic drug …

Especially critically ill children are exposed to antibiotic overtreatment, mainly caused by the
fear of missing out a severe bacterial infection. Potential adverse effects and selection of …