The distant and selective activation of unreactive C–H and C–C bonds remains one of the
biggest challenges in organic chemistry. In recent years, the development of remote …

Conspectus α-Amino acids (αAA) are one of the most useful chiral building blocks for
synthesis. There are numerous general strategies that have commonly been used for αAA …

Fully automated synthetic chemistry would substantially change the field by providing broad
on-demand access to small molecules. However, the reactions that can be run …

Design of ligands in transition-metal catalyzed reactions is challenging, especially in
asymmetric transformations. With each step in the catalytic cycle promoted by its privileged …

In recent years, the pharmaceutical market has experienced a paradigm shift; as small
molecules had long been thought of as the ultimate therapeutics, the use of biologics …

The synergistic combination of NiH-catalyzed alkene isomerization with nickel-catalyzed
cross-coupling has yielded a general protocol for the synthesis of a wide range of …

A highly efficient strategy for remote reductive cross-electrophile coupling has been
developed through the ligand-controlled nickel migration/arylation. This general protocol …

Transition-metal-catalyzed C–H bond functionalization has known a rapid evolution in the
last years, offering modern strategies for reaching high molecular complexity in a step-and …

Although the syntheses of novel and diverse peptides rely mainly on traditional coupling
using unnatural amino acids, postsynthetic modification of peptides could provide a …

A NiH‐catalyzed migratory hydroalkenylation reaction of olefins with alkenyl bromides has
been developed, affording benzylic alkenylation products with high yields and excellent …