Abstract JASPAR (https://jaspar. elixir. no/) is a widely-used open-access database
presenting manually curated high-quality and non-redundant DNA-binding profiles for …

Antibodies are used in many areas of biomedical and clinical research, but many of these
antibodies have not been adequately characterized, which casts doubt on the results …

Large-scale generation of protein capture reagents remains a technical challenge, but their
generation is just the beginning. Validation is a critical, iterative process that yields different …

Formerly hailed as “undruggable” proteins, transcription factors (TFs) are now under
investigation for targeted therapy. In cancer, this may alter, inter alia, immune evasion or …

Genetic variants are involved in the orchestration of alternative polyadenylation (APA)
events, while the role of DNA methylation in regulating APA remains unclear. We generated …

In this study, we introduce TESA (weighted two-stage alignment), an innovative motif
prediction tool that refines the identification of DNA-binding protein motifs, essential for …

In our cells, a limited number of RNA binding proteins (RBPs) are responsible for all aspects
of RNA metabolism across the entire transcriptome. To accomplish this, RBPs form …

Abstract Cleavage Under Targets and Release Using Nuclease (CUT&RUN) is a recent
development for epigenome mapping, but its unique methodology can hamper proper …

Transcriptional regulation is a process by which cells produce the necessary elements to
respond to a given condition. A core element of this process is the interplay between cis …

RNA switches are key regulators of gene expression in bacteria, yet very few have been
described and characterized in Metazoa. Here, we present an integrative computational and …