Virus-like particle vaccinology, from bench to bedside
MO Mohsen, MF Bachmann - Cellular & molecular immunology, 2022 - nature.com
Virus-like particles (VLPs) have become key tools in biology, medicine and even
engineering. After their initial use to resolve viral structures at the atomic level, VLPs were …
engineering. After their initial use to resolve viral structures at the atomic level, VLPs were …
Advances in recombinant antibody manufacturing
R Kunert, D Reinhart - Applied microbiology and biotechnology, 2016 - Springer
Since the first use of Chinese hamster ovary (CHO) cells for recombinant protein expression,
production processes have steadily improved through numerous advances. In this review …
production processes have steadily improved through numerous advances. In this review …
Customized yeast cell factories for biopharmaceuticals: from cell engineering to process scale up
A Madhavan, KB Arun, R Sindhu… - Microbial Cell …, 2021 - Springer
The manufacture of recombinant therapeutics is a fastest-developing section of therapeutic
pharmaceuticals and presently plays a significant role in disease management. Yeasts are …
pharmaceuticals and presently plays a significant role in disease management. Yeasts are …
Microbial factories for recombinant pharmaceuticals
N Ferrer-Miralles, J Domingo-Espín, JL Corchero… - Microbial cell …, 2009 - Springer
Most of the hosts used to produce the 151 recombinant pharmaceuticals so far approved for
human use by the Food and Drug Administration (FDA) and/or by the European Medicines …
human use by the Food and Drug Administration (FDA) and/or by the European Medicines …
Platforms, advances, and technical challenges in virus-like particles-based vaccines
R Gupta, K Arora, SS Roy, A Joseph… - Frontiers in …, 2023 - frontiersin.org
Viral infectious diseases threaten human health and global stability. Several vaccine
platforms, such as DNA, mRNA, recombinant viral vectors, and virus-like particle-based …
platforms, such as DNA, mRNA, recombinant viral vectors, and virus-like particle-based …
Yeast-based vaccines: New perspective in vaccine development and application
R Kumar, P Kumar - FEMS yeast Research, 2019 - academic.oup.com
In presently licensed vaccines, killed or attenuated organisms act as a source of
immunogens except for peptide-based vaccines. These conventional vaccines required a …
immunogens except for peptide-based vaccines. These conventional vaccines required a …
Bioprocess engineering aspects of heterologous protein production in Pichia pastoris: a review
Pichia pastoris is currently one of the most effective and versatile systems for the expression
of heterologous proteins. Its success is due to its powerful methanol-inducible alcohol …
of heterologous proteins. Its success is due to its powerful methanol-inducible alcohol …
Virus‐like particles as powerful vaccination strategy against human viruses
I Hadj Hassine, M Ben M'hadheb… - Reviews in Medical …, 2024 - Wiley Online Library
Nowadays, viruses are not only seen as causative agents of viral infectious diseases but
also as valuable research materials for various biomedical purposes, including recombinant …
also as valuable research materials for various biomedical purposes, including recombinant …
GoldenPiCS: a Golden Gate-derived modular cloning system for applied synthetic biology in the yeast Pichia pastoris
R Prielhofer, JJ Barrero, S Steuer, T Gassler… - BMC Systems …, 2017 - Springer
Background State-of-the-art strain engineering techniques for the host Pichia pastoris (syn.
Komagataella spp.) include overexpression of homologous and heterologous genes, and …
Komagataella spp.) include overexpression of homologous and heterologous genes, and …
Yeast-based virus-like particles as an emerging platform for vaccine development and delivery
Virus-like particles (VLPs) are empty, nanoscale structures morphologically resembling
viruses. Internal cavity, noninfectious, and particulate nature with a high density of repeating …
viruses. Internal cavity, noninfectious, and particulate nature with a high density of repeating …