Osteoarthritis (OA) is a type of joint disease associated with wear and tear, inflammation,
and aging. Mechanical stress along with synovial inflammation promotes the degradation of …

Increases in adipocyte volume and tissue mass due to obesity can result in inflammation,
further dysregulation in adipose tissue function, and eventually adipose tissue fibrosis. Like …

A defining characteristic of pulmonary hypertension (PH) is the extensive remodeling of
pulmonary arteries (PAs), which results in progressive increases in vascular resistance and …

Cellular components, surface layer protein (SLP) and exopolysaccharides (EPS) of
postbiotic lactic bacteria (PLAB) can rehabilitate high-fat diet-induced dysbiosis and obese …

Background Elevated levels of periostin (Postn) in the cartilage and bone are associated
with osteoarthritis (OA). However, it remains unknown whether Postn loss-of-function can …

BACKGROUND: Perivascular adipose tissue (PVAT) is vital for vascular homeostasis, and
PVAT dysfunction is associated with increased atherosclerotic plaque burden. But the …

Adipose is a key tissue regulating energy homeostasis. In states of obesity, caloric intake
exceeds energy expenditure, thereby accelerating lipid accumulation with ongoing …

Several studies have suggested that extracellular matrix (ECM) remodeling and the
microenvironment are tightly associated with adipogenesis and adipose angiogenesis. In …

Osteoarthritis (OA) is characterized by progressive loss of articular cartilage accompanied by
the new bone formation and, often, a synovial proliferation that culminates in pain, loss of …

In this study, we aimed to comprehensively characterize the proteomic landscapes of
subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) in patients with …